Fig. 3

Actionability of genes in receptor tyrosine kinase (RTK)-related pathways. Receptor tyrosine kinases (RTK) (a), the PI3K/AKT/MTOR pathway (b), and the RAS/MAPK pathway (c) and are displayed. Oncoprint plots are depicted for genetic alterations and their postulated actionability in RTK genes (d), genes of the PI3K/AKT/MTOR pathway (e), and genes of the RAS/MAPK pathway (f). The differential distribution of genetic alterations for ERBB2 (g), PIK3CA (h), KRAS (i) and NF1 (j) between histological subtypes is shown in bar charts. All statistical analyses were performed by the Chi-Square test (see Additional file 7). Statistical significance is displayed as *P < 0.05, and **P < 0.01. Histological subtypes are abbreviated as HGS = high-grade serous, E = endometrioid and CC = clear cell. MAP 2 K1 = MEK1, MAP 2 K2 = MEK2 and MAPK1 = ERK2. In oncoprint plots, * indicates a sample with low (20–30%) tumor purity