Fig. 5

PHF19 overexpression reversed the effect of LINC_00355 knockdown on the development of GC. After HGC-27 and MKN45 cells were co-transfected with si-LINC_00355 and pcDNA3.1-PHF19 plasmid, cell viability, migration, invasion, and apoptosis were detected (a-d). The expression levels of pro/cleaved caspase 3, cyclin D1, cyclin E, matrix metalloproteinase (MMP) 9, and MMP2 were detected by western blot analysis (e). All values were expressed as mean ± standard deviation. n = 3. *P < 0.05 compared with si-NC + vector group and ^#P < 0.05 compared with si-LINC_00355 + vector group. GC, gastric cancer; NC, negative control