Table 1 Upfront ABI group

n

20

46

Age^a (years) (mean, SD)

72 (6)

71 (6)

0.231

ECOG-PS^b (median, IQR)

0 (0-1)

0 (0-0)

0.039

Initial PSA^b (ng/mL) (median, IQR)

961 (314-2702)

189 (51-448)

0.001

Gleason score^b (median, IQR)

9 (8-10)

9 (8-9)

0.649

Visceral metastasis^c

3 (15%)

11 (24%)

0.524

Lung

2

11

-

Liver

1

0

-

Others

0

0

-

EOD^b (median, IQR)

3 (2-3)

2 (2-3)

0.002

ALP^b (IU/L) (median, IQR)

949 (372-1684)

357 (258-717)

0.010

LDH^b (IU/L) (median, IQR)

233 (200-279)

199 (166-227)

0.017

Discontinuation of ABI due to AEs^c

1 (5.0%)

2 (4.3%)

1.000

Clinical progression^c

(CRPC or PC death before CRPC)

10 (50%)

5 (11%)

<0.001

CRPC^c

9 (43%)

5 (11%)

0.002

PC death before CRPC^c

1 (5.0%)

0 (0%)

0.303

Death after CRPC^c

1 (5.0%)

1 (2.3%)

0.518

Follow-up period^b (months) (median, IQR)

11 (11-15)

13 (11-17)

0.130