Fig. 1

Evaluation of PC9 Luc⁺ cell tumorigenicity and response to osimertinib. PC-9 Luc⁺ cells were injected sc in Balb/c nude mice. Tumor growth was assessed by caliper measurements (a) and bioluminescence (a & b). a Tumor sizes are expressed in mm³ and tumor bioluminescence intensity is expressed as cpm/cm² for the thoracic area (mean ± SEM, n = 5). b Pictures show representative results for bioluminescence in tumor-bearing mice on days 14, 21 and 28 after tumor cell injection. c Tumor-bearing mice were either treated or not (none) with osimertinib 1 mg/kg, 5 days/week or with paclitaxel (paclitaxel AHCL) 20 mg/kg, 2 days/week, from day 15 after tumor cell injection to the end of the experiment. Tumor growth was assessed by caliper measurements and tumor sizes are expressed in mm³ (mean ± SEM, n = 6)