Association of ZNF331 and WIF1 methylation in peripheral blood leukocytes with the risk and prognosis of gastric cancer

Table 5 Association between the methylation status of ZNF331 and WIF1 and GC prognosis

Methylation status		Case(%)	Crude HR(95%CI)	P	HR^a (95%CI)	P	HR^b (95%CI)	P
ZNF331	Hm	157 (45.1)	0.960 (0.713–1.293)	0.788	1.088 (0.799–1.483)	0.592	1.052 (0.759–1.457)	0.762
ZNF331	Lm	191 (54.9)	1.000		1.000		1.000
WIF1	Hm	84 (23.9)	0.892 (0.625–1.272)	0.528	0.852 (0.592–1.225)	0.386	0.830 (0.568–1.215)	0.338
WIF1	Lm	267 (76.1)	1.000		1.000		1.000

Lm low methylation, Hm high methylation, CI confidence interval, HR hazard ratio, GC gastric cancer
^a Adjusted for age, sex, BMI, tumor size, TNM stage
^b Adjusted for propensity score of all variables

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