Table 2 EC50 values for the single compounds and the combination
Cell line | EC50 DCA (mM) | EC50 PX-478 (μM) | EC50 Combination DCA (mM)/PX-478 (μM) | Best CI |
|---|---|---|---|---|
A549 (lung) | 41.9 | 30 | 14.2/15.8 | 0.61 |
H441 (lung) | 38.6 | 23.5 | 8.3/11.9 | 0.78 |
HeLa (cervical) | 21.2 | 13.4 | 8.9/5.8 | 0.57 |
HEPG2 (hepatocellular) | 21.4 | 17.7 | 8.4/6.3 | 0.56 |
HT-29 (colon) | 26.5 | 75.6 | 18.1/28.2 | 0,65 |
MCF-7 (breast) | 31.5 | 11.2 | 10.2/4 | 0.4 |
MDA-MB-231 (breast) | 26.1 | 276 | 23.4/79 | 0.8 |
U251 (glioblastoma) | 25 | 30.5 | 9.5/16.8 | 0.6 |