Table 4 Prognostic factors for overall survival of the patients in different therapy groups by using the Cox proportional hazard model
From: Surgical choice of non-small cell lung cancer with unexpected pleural dissemination intraoperatively
Variables | Targeted therapy | Chemotherapy alone | ||||||
|---|---|---|---|---|---|---|---|---|
Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | |||||
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Sex | ||||||||
 Male vs female | 1.947 (0.746 - 5.082) | 0.173 | - | - | 1.367 (0.673 - 2.776) | 0.388 | - | - |
Smoking status | ||||||||
 Yes vs no | 1.677 (0.586 - 4.804) | 0.335 | - | - | 1.519 (0.776 - 2.972) | 0.223 | - | - |
Comorbidities | ||||||||
 Yes vs no | 1.018 (0.292 - 3.544) | 0.978 | - | - | 1.557 (0.733 - 3.310) | 0.250 | - | - |
Clinical T stage | ||||||||
 3-4 vs 1-2 | 1.842 (0.418 - 8.116) | 0.420 | 1.214 (0.231 - 6.365) | 0.819 | 2.100 (0.995 - 4.430) | 0.051 | 1.921 (1.031 - 3.581) | 0.040 |
Clinical N stage | ||||||||
 1-2 vs 0 | 1.668 (0.631 - 4.410) | 0.302 | 1.458 (0.488 - 4.353) | 0.500 | 1.234 (0.646 - 2.357) | 0.524 | 1.312 (0.777 - 2.213) | 0.309 |
Pleural effusion | ||||||||
 Yes vs no | 1.717 (0.627 - 4.704) | 0.293 | - | - | 2.219 (1.134 - 4.341) | 0.020 | 1.538 (0.847 - 2.793) | 0.157 |
Surgical method | ||||||||
 Tumor resection vs open-close | 0.649 (0.246 - 1.710) | 0.382 | 0.684 (0.240 - 1.946) | 0.476 | 0.322 (0.165 - 0.628) | < 0.001 | 0.546 (0.298 - 0.999) | 0.049 |
Time point of TKIs | ||||||||
 First-line | 1.000 | - | 1.000 | - | - | - | - | - |
 Maintenance after chemotherapy | 1.482 (0.483 - 4.554) | 0.492 | 1.354 (0.434 - 4.623) | 0.601 | - | - | - | - |
 Second-line | 0.978 (0.260 - 3.678) | 0.974 | 1.164 (0.293 - 4.623) | 0.829 | - | - | - | - |
III generation TKIs | ||||||||
 Yes vs no | 0.659 (0.148 - 2.927) | 0.584 | 0.728 (0.153 - 3.467) | 0.690 | - | - | - | - |