Comprehensive analyses of competing endogenous RNA networks reveal potential biomarkers for predicting hepatocellular carcinoma recurrence

Table 3 Relationship between the prognostic four-gene signature and other clinicopathlogical features in the TCGA cohort and the TFAHCQMU cohort

Clinicopathological variables	TCGA cohort			TFAHCQMU cohort
	Low risk	High risk	P-value	Low risk	High risk	P-value
Age			0.655			0.108
< 60	72	76		19	13
≥60	89	85		6	11
Gender			0.012*			0.675
Male	121	100		20	18
Female	40	61		5	6
Cirrhosis			0.862			0.308
Negative	64	51		13	9
Positive	41	31		12	15
AJCC stage			0.016*			0.049*
I-II	124	106		24	18
III-IV	28	46		1	6
Tumor grade			0.758			0.928
I-II	103	101		18	17
III-IV	56	59		7	7
Vascular invasion			0.028*			0.004**
Negative	105	81		22	12
Positive	40	54		3	12

TCGA, The Cancer Genome Atlas; TFAHCQMU, the First Affiliated Hospital of Chongqing medical university;
The median of the four-gene signature score was used as the cut-off values to divide HCC patients into the high-risk group and the low-risk group
Chi square test was used for comparison between two groups
*P-value< 0.05, **P-value< 0.01,***P-value< 0.001

ISSN: 1471-2407