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Table 2 Concordance between STRAT4 and IHC for core biopsy and surgical specimens

From: Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical specimens

Comparisons Target True
pos
True
neg
False
pos
False
neg
OPA (%) PPA (%) NPA (%) PPV (%) NPV (%) Kappa
(95% CIa)
STRAT4 vs IHC, both CNB ER 85 12 1 2 97.0 97.7 92.3 98.8 85.7 0.87 (0.73–1.0)
PR 76 13 9 2 89.0 97.4 59.1 89.4 86.7 0.64 (0.44–0.83)
Ki-67 37 39 22 2 76.0 94.9 63.9 62.7 95.1 0.54 (0.39–0.69)
HER2 18 69 13 0 87.0 100.0 84.1 58.1 100.0 0.66 (0.49–0.82)
STRAT4 vs IHC, both surgical specimen ER 85 11 2 2 96.0 97.7 84.6 97.7 84.6 0.82 (0.65–0.99)
PR 78 14 5 3 92.0 96.3 73.7 94.0 82.4 0.73 (0.55–0.91)
Ki-67 39 39 14 8 78.0 83.0 73.6 73.6 83.0 0.56 (0.40–0.72)
HER2 17 74 8 1 91.0 94.4 90.2 68.0 98.7 0.73 (0.57–0.89)
CNB vs surgical specimen, both STRAT4 ER 86 13 0 1 99.0 99 100 100 93 0.96 (0.87–1.0)
PR 81 13 4 2 94.0 98 76 95 87 0.78 (0.61–0.95)
Ki-67 44 32 15 9 76.0 83 68 75 78 0.51 (0.35–0.68)
HER2 21 65 10 4 86.0 84 87 68 94 0.65 (0.49–0.82)
  1. aCohen’s kappa κ-values: > 0.8 indicated very good agreement, between 0.6 and 0.8 indicated good agreement between 0.4 and 0.6 was considered as moderate agreement, < 0.4 as fair, < 0.2 as poor agreement