Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

Table 3 ADC patient characteristics and stratification by neuroendocrine marker

	ADC overall cohort		ADC neuroendocrine marker positive		ADC neuroendocrine marker negative		p value
	n	%	n	%	n	%
Patients	627	100	110	100	517	100
Gender
Male	365	58	67	61	298	58	0.528
Female	262	42	43	39	219	42
Age, median y (range)	63 (30–89)		63 (41–84)		63 (30–89)		0.373
TNM
pT
pT1	127	20	25	23	102	20	0.535
pT2	388	62	63	57	325	63
pT3	94	15	17	15	77	15
pT4	18	3	5	5	13	3
pN
pN0	314	50	63	57	251	49	0.068^a
pN1	94	15	14	13	80	15
pN2	192	31	28	25	164	32
pN3	5	1	0	0	5	1
pNX	22	4	5	5	17	3
pM
pM1	26	4	2	2	24	5
pMX	601	96	108	98	493	95
Stage
I	254	41	46	42	208	40	0.153^b
II	130	21	29	26	101	20
III	217	35	33	30	184	36
IV	26	4	2	2	24	5
Genetic aberrations
KRAS	147^c	36	29^d	36	118^e	36	0.732^f
EGFR	64^c	16	10^d	8	52	16
BRAF	14^c	3	2^d	3	12	4
ROS1	5^c	1	1^d	1	4	1
ALK	5^c	1	0^d	0	5	2

ISSN: 1471-2407