Table 1 Performances of biomarkers for the diagnosis of HCC patients
AUC(95%CI) | Cutoff value | Sensitivity(%)(95%CI) | Specificity(%)(95%CI) | Z test | P Value | |
|---|---|---|---|---|---|---|
HCC vs Healthy controls | ||||||
PIVKA-II | 0.90 (0.88–0.94) | 35.60mAU/ml | 83.93 (77.63–88.71) | 91.50 (86.01–94.97) | ||
AFP | 0.77 (0.72–0.82) | 17.76 ng/ml | 64.29 (56.80–71.14) | 90.20 (84.45–93.97) | ||
PIVKA-II + AFP | 0.94 (0.92–0.97)* | 87.50 (81.65–91.68) | 92.50 (86.01–94.97) | 6.756 | < 0.01 | |
HCC vs Benign liver diseases | ||||||
PIVKA-II | 0.85 (0.81–0.89) | 43.47mAU/ml | 81.55 (75.00–86.68) | 86.00 (79.54–90.66) | ||
AFP | 0.72 (0.66–0.77) | 21.47 ng/ml | 63.10 (55.58–70.02) | 84.67 (78.04–89.56) | ||
PIVKA-II + AFP | 0.90 (0.87–0.94)* | 81.95 (74.35–86.17) | 89.33 (83.38–93.33) | 6.744 | < 0.01 | |