Table 1 Characteristics of the included studies
Author/published year | Induction arms (randomized) | Induction sample size | Induction regimen | Induction Cycles | Dose of Bevacizumab | Maintenance arms (randomized) | Maintenance sample size | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|---|---|---|
Patel, 2013 (PointBreak) [14] | Pem + Cb + Bev (randomized) | 442 | Pem 500 mg/m2, Cb AUC 6, Bev 15 mg/kg, day 1 every 3 weeks | 4 | 15 mg/kg | Pem + Bev | 292 | OS | PFS, ORR, DCR, TTPD, toxicity |
|  | Pac + Cb + Bev (randomized) | 443 | Pac 200 mg/m2, Cb AUC 6, Bev 15 mg/kg, day 1 every 3 weeks |  |  | Bev | 298 |  | – |
Zinner, 2015 (PRONOUNCE) [15] | Pem + Cb (randomized) | 182 | Pem 500 mg/m2, Cb AUC 6, day 1 every 3 weeks | 4 | 15 mg/kg | Pem | 121 | PFS without grade 4 toxicity | PFS, OS, ORR, DCR, safety |
|  | Pac + Cb + Bev (randomized) | 179 | Pac 200 mg/m2, Cb AUC 6, Bev 15 mg/kg, day 1 every 3 weeks |  |  | Bev | 113 |  |  |
Galetta, 2015 (ERACLE) [16] | Pem + Cis (randomized) | 60 | Pem 500 mg/m2, Cis 75 mg/m2, day 1 every 3 weeks | 6 | 15 mg/kg | Pem | 44 | QOL | PFS, OS, ORR, safety |
|  | Pac + Cb + Bev (randomized) | 58 | Pac 200 mg/m2, Cb AUC 6 Bev 15 mg/kg, day 1 every 3 weeks |  |  | Bev | 30 |  |  |
Barlesi, 2014 (AVAPERL) | Pem + Cis + Bev | 376 | Pem 500 mg/m2, Cis 75 mg/m2, Bev 7.5 mg/kg, day 1 every 3 weeks | 4 | 7.5 mg/kg | Pem + Bev (randomized) | 128 | PFS | OS, ORR, DOR |
| Â | Â | Â | Â | Â | Â | Bev (randomized) | 125 | Â | Â |
Ramalingam, 2019 (EA5508) [12] | Pac + Cb + Bev | 1432 | Pac 200 mg/m2, Cb AUC 6, Bev 15 mg/kg, day 1 every 3 weeks | 4 | 15 mg/kg | Bev (randomized) | 287 | OS | PFS, ORR, safety |
| Â | Â | Â | Â | Â | Â | Pem (randomized) | 294 | Â | Â |
|  |  |  |  |  |  | Pem + Bev (randomized) | 293 |  |  |
Seto, 2019 (COMPASS) [11] | Pem + Cb + Bev | 907 | Pem 500 mg/m2, Cb AUC 6, Bev 15 mg/kg, day 1 every 3 weeks | 4 | 15 mg/kg | Bev (randomized) | 295 | OS (from Random Assignment) | PFS and OS (from induction therapy), safety |
|  |  |  |  |  |  | Pem + Bev (randomized) | 299 |  |  |