Fig. 7

SNP density (number of SNPs per Kb CDS) in different genes. The high-confidence SNPs were used in this part (coverage ≥20, alternative allele ≥3, and absent in 1000-genomes). a Optimal synonymous SNP density in oncogenes and TSG. KS test was used to calculate p-value. b Non-optimal synonymous SNP density in oncogenes and TSG. KS test was used to calculate p-value. c Synonymous SNP density in the remaining genes. KS test was used to calculate p-value. d Regression coefficients of “Y ~ X1 + X2 + ...Xn”. Y is the TE fold change of tumor samples to normal samples. The variables included the number of optimal synonymous mutations and the number of non-optimal synonymous mutations