Fig. 3

PIK3CA + HMCN1 mutation as the marginal factor can mitigate the poor survival of the LRP1B and AHNAK2 mutational subtypes by interacting within a higher-order combination. a The most frequently found mutational partners of PIK3CA mutation within all higher-order combinations in STAD, BRCA and COAD. The x-axis denotes the frequency. The y-axis denotes the cancer type. b Dimutation of PIK3CA + HMCN1 produced a beneficial marginal effect on the HR compared with the LRP1B mutation in 60% of the STAD patient samples selected at random (the exploration set). The x-axis denotes the survival time. The y-axis denotes the survival probability. c Dimutation of PIK3CA + HMCN1 produced a beneficial marginal effect on the HR compared with AHNAK2 mutation in 60% of the STAD patient samples selected at random (the exploration set). The x-axis denotes the survival time. The y-axis denotes the survival probability