Fig. 1

Systematic enumeration of higher-order mutational combinations within multiple genetic orders from STAD, BRCA, and COAD patient cohorts. a Plot of the hazard ratios for all combinatorial gene sets. The x-axis denotes the genetic combination species. The y-axis denotes the log10 (hazard ratio) + 1 value. The red dashed line distinguishes the adverse and beneficial effect zones. b Plot of coverage for all combinatorial gene sets. The x-axis denotes the genetic combination species. The y-axis denotes the relative proportion (%). c The proportion of PIK3CA mutations within the multiplexed combinations in each tumor type. The x-axis denotes the species of genetic combination. The y-axis denotes the relative proportion (%). d Kaplan-Meier survival curves of two patient cohorts from STAD, BRCA, and COAD patients carrying PIK3CA mutations presented in lower-order or higher-order mutational gene sets. The significance of the gene sets for predicting survival was calculated by using the log-rank test. The x-axis denotes the survival time. The y-axis denotes the survival probability