Table 3 Association of SNPs and astrocytoma risk stratified by WHO grade
Gene | SNP ID | Model | Genotype | LGA | HGA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Controls | Cases | OR (95% CI) | p | Controls | Cases | OR (95% CI) | p | ||||
CYP19A1 | rs2255192 | Codominant | C/C | 257 (68.0%) | 150 (63.6%) | 1.00 | 0.058 | 257 (68.0%) | 83 (65.3%) | 1.00 | 0.800 |
C/T | 109 (28.8%) | 71 (30.1%) | 1.31 (0.81–2.13) | 109 (28.8%) | 41 (32.3%) | 1.11 (0.71–1.73) | |||||
T/T | 12 (3.2%) | 15 (6.4%) | 3.33 (1.20–9.23) | 12 (3.2%) | 3 (2.4%) | 0.76 (0.20–2.82) | |||||
Dominant | C/C | 257 (68.0%) | 150 (63.6%) | 1.00 | 0.096 | 257 (68.0%) | 83 (65.3%) | 1.00 | 0.740 | ||
C/T-T/T | 121 (32.0%) | 86 (36.4%) | 1.48 (0.93–2.35) | 121 (32.0%) | 44 (34.6%) | 1.08 (0.70–1.66) | |||||
Recessive | C/C-C/T | 366 (96.8%) | 221 (93.6%) | 1.00 | 0.034 | 366 (96.8%) | 124 (97.6%) | 1.00 | 0.630 | ||
T/T | 12 (3.2%) | 15 (6.4%) | 3.05 (1.11–8.34) | 12 (3.2%) | 3 (2.4%) | 0.73 (0.20–2.71) | |||||
Additive | – | – | – | 1.53 (1.04–2.24) | 0.030 | – | – | 1.03 (0.71–1.50) | 0.880 | ||
rs4646 | Codominant | C/C | 188 (49.7%) | 120 (50.6%) | 1.00 | 0.420 | 188 (49.7%) | 74 (58.3%) | 1.00 | 0.044 | |
C/A | 163 (43.1%) | 103 (43.5%) | 0.76 (0.48–1.20) | 163 (43.1%) | 40 (31.5%) | 0.61 (0.39–0.95) | |||||
A/A | 27 (7.1%) | 14 (5.9%) | 0.66 (0.24–1.80) | 27 (7.1%) | 13 (10.2%) | 1.24 (0.60–2.55) | |||||
Dominant | C/C | 188 (49.7%) | 120 (50.6%) | 1.00 | 0.200 | 188 (49.7%) | 74 (58.3%) | 1.00 | 0.083 | ||
C/A-A/A | 190 (50.3%) | 117 (49.4%) | 0.75 (0.48–1.17) | 190 (50.3%) | 53 (41.7%) | 0.69 (0.46–1.05) | |||||
Recessive | C/C-C/A | 351 (92.9%) | 223 (94.1%) | 1.00 | 0.570 | 351 (92.9%) | 114 (89.8%) | 1.00 | 0.250 | ||
A/A | 27 (7.1%) | 14 (5.9%) | 0.76 (0.28–2.01) | 27 (7.1%) | 13 (10.2%) | 1.52 (0.75–3.07) | |||||
Additive | – | – | – | 0.78 (0.53–1.14) | 0.190 | – | – | 0.87 (0.62–1.20) | 0.390 | ||