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Table 3 Univariate and multivariate analyses of CSS in locally advanced OSCC patients

From: Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection

Characteristics Univariate analysis Multivariate analysis
SHR(95%CI) P Value SHR(95%CI) P Value
Age 1.372 (1.221–1.541) 0 1.05 (1.029–1.071) 0
Gender
 Female Ref    
 Male 1.034 (0.908–1.179) 0.612   
KFI
  < 2 Ref   Ref  
  ≥ 2 1.389 (1.087–1.776) 0.009 1.706 (1.109–2.624) 0.015
Smoking
 No Ref    
 Yes 1.284 (0.904–1.824) 0.163   
pT   0   0.004
 T1 Ref   Ref  
 T2 2.317 (1.424–3.771) 0.001 3.122 (1.252–7.782) 0.015
 T3 2.869 (1.79–4.598) 0 5.073 (2.077–12.392) 0
 T4 4.317 (2.728–6.831) 0 4.428 (1.762–11.129) 0.002
pN   0.073   .625
 N0 Ref   Ref  
 N1 0.641 (0.445–0.924) 0.017 0.871 (0.451–1.68) 0.68
 N2 0.825 (0.618–1.101) 0.192 1.127 (0.648–1.96) 0.671
 N3 1.078 (0.656–1.773) 0.766 1.575 (0.626–3.965) 0.335
AJCC Stage
 III Ref   Ref  
 IV 1.728 (1.413–2.113) 0 0.750 (0.513–1.095) 0.136
Perineural invasion
 No Ref    
 Yes 1.225 (0.844–1.777) 0.285   
Tumor differentation   0.235   
 Well differentiated Ref    
 Moderately differentiated 1.774 (0.627–5.016) 0.28   
 Poorly differentiated 2.252 (0.61–8.315) 0.223   
Depth of tumor invasion
  < 20 mm Ref    
  ≥ 20 mm 2.298 (0.537–9.834) 0.262   
Number of Positive Nodes   .009   0.009
 0 Ref   Ref  
 1–2 1.564 (1.076–2.272) 0.019 1.432 (1.003–2.044) 0.048
 3–4 2.079 (1.307–3.308) 0.002 1.679 (1.097–2.569) 0.017
  ≥ 5 2.487 (1.572–3.935) 0.0001 2.413 (1.349–4.318) 0.003
Lymphovascular invasion (%)
 No Ref    
 Yes 2.672 (0.639–11.172) 0.178   
Primary Tumor Site
 Tongue Ref    
 Floor of mouth 1.815 (0.593–5.55) 0.296   
 Other 1.865 (0.775–4.483) 0.164   
Extracapsular extension
 No Ref    
 Yes 1.866 (0.775–4.494) 0.164   
Bone invasion
 No Ref    
 Yes 1.689 (0.789–3.614) 0.177   
Safety Margins
  < 5 mm Ref    
  ≥ 5 mm 1.699 (0.772–3.74) 0.188   
SII
  < 535.5 Ref   Ref  
  ≥ 535.5 2.732 (1.149–6.498) 0.023 2.214 (1.289–3.805) 0.004
NLR
  < 2.8 Ref   Ref  
  ≥ 2.8 1.164 (1.022–1.326) 0.022 1.502 (0.729–3.096) 0.27
PLR
  < 162.5 Ref   Ref  
  ≥ 162.5 1.861 (1.048–3.304) 0.034 2.246 (0.732–6.885) 0.157
  1. Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index
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