Table 3 Univariate and multivariate analyses of CSS in locally advanced OSCC patients

Age

1.372 (1.221–1.541)

0

1.05 (1.029–1.071)

0

 Female

Ref

 Male

1.034 (0.908–1.179)

0.612

  < 2

Ref

Ref

  ≥ 2

1.389 (1.087–1.776)

0.009

1.706 (1.109–2.624)

0.015

 No

Ref

 Yes

1.284 (0.904–1.824)

0.163

pT

0

0.004

 T1

Ref

Ref

 T2

2.317 (1.424–3.771)

0.001

3.122 (1.252–7.782)

0.015

 T3

2.869 (1.79–4.598)

0

5.073 (2.077–12.392)

0

 T4

4.317 (2.728–6.831)

0

4.428 (1.762–11.129)

0.002

pN

0.073

.625

 N0

Ref

Ref

 N1

0.641 (0.445–0.924)

0.017

0.871 (0.451–1.68)

0.68

 N2

0.825 (0.618–1.101)

0.192

1.127 (0.648–1.96)

0.671

 N3

1.078 (0.656–1.773)

0.766

1.575 (0.626–3.965)

0.335

 III

Ref

Ref

 IV

1.728 (1.413–2.113)

0

0.750 (0.513–1.095)

0.136

 No

Ref

 Yes

1.225 (0.844–1.777)

0.285

Tumor differentation

0.235

 Well differentiated

Ref

 Moderately differentiated

1.774 (0.627–5.016)

0.28

 Poorly differentiated

2.252 (0.61–8.315)

0.223

  < 20 mm

Ref

  ≥ 20 mm

2.298 (0.537–9.834)

0.262

Number of Positive Nodes

.009

0.009

 0

Ref

Ref

 1–2

1.564 (1.076–2.272)

0.019

1.432 (1.003–2.044)

0.048

 3–4

2.079 (1.307–3.308)

0.002

1.679 (1.097–2.569)

0.017

  ≥ 5

2.487 (1.572–3.935)

0.0001

2.413 (1.349–4.318)

0.003

 No

Ref

 Yes

2.672 (0.639–11.172)

0.178

 Tongue

Ref

 Floor of mouth

1.815 (0.593–5.55)

0.296

 Other

1.865 (0.775–4.483)

0.164

 No

Ref

 Yes

1.866 (0.775–4.494)

0.164

 No

Ref

 Yes

1.689 (0.789–3.614)

0.177

  < 5 mm

Ref

  ≥ 5 mm

1.699 (0.772–3.74)

0.188

  < 535.5

Ref

Ref

  ≥ 535.5

2.732 (1.149–6.498)

0.023

2.214 (1.289–3.805)

0.004

  < 2.8

Ref

Ref

  ≥ 2.8

1.164 (1.022–1.326)

0.022

1.502 (0.729–3.096)

0.27

  < 162.5

Ref

Ref

  ≥ 162.5

1.861 (1.048–3.304)

0.034

2.246 (0.732–6.885)

0.157