Characteristics | Univariate analysis | P Value | Multivariate analysis | P Value |
---|---|---|---|---|
HR(95%CI) | HR(95%CI) | |||
Gender | ||||
 Female | Ref |  |  |  |
 Male | 1.034 (0.908–1.179) | 0.612 |  |  |
Age | 1.024 (1.014–1.035) | < 0.001 | 1.023 (1.012–1.033) | < 0.001 |
KFI | ||||
  < 2 | Ref |  | Ref |  |
  ≥ 2 | 1.389 (1.087–1.776) | 0.009 | 1.458 (1.137–1.871) | 0.003 |
Smoking | ||||
 No | Ref |  |  |  |
 Yes | 1.284 (0.904–1.824) | 0.163 |  |  |
pT |  | < 0.001 |  | < 0.001 |
 T1 | Ref |  | Ref |  |
 T2 | 2.317 (1.424–3.771) | 0.001 | 2.128 (1.303–3.477) | 0.003 |
 T3 | 2.869 (1.79–4.598) | 0 | 3.157 (1.945–5.124) | 0 |
 T4 | 4.317 (2.728–6.831) | 0 | 4.316 (2.674–6.966) | 0 |
pN | Â | .073 | Â | .065 |
 N0 | Ref |  | Ref |  |
 N1 | 0.641 (0.445–0.924) | 0.017 | 1.031 (0.701–1.517) | 0.876 |
 N2 | 0.825 (0.618–1.101) | 0.192 | 1.358 (0.99–1.864) | 0.058 |
 N3 | 1.078 (0.656–1.773) | 0.766 | 1.685 (1.01–2.811) | 0.046 |
AJCC Stage | ||||
 III | Ref |  | Ref |  |
 IV | 1.526 (1.863–1.251) | < 0.001 | 1.358 (0.99–1.864) | 0.058 |
Perineural invasion | ||||
 No | Ref |  |  |  |
 Yes | 1.428 (0.778–2.618) | 0.250 |  |  |
Tumor differentation | Â | 0.224 | Â | Â |
 Well differentiated | Ref |  |  |  |
 Moderately differentiated | 1.385 (0.856–2.241) | 0.184 |  |  |
 Poorly differentiated | 2.581 (0.452–14.724) | 0.286 |  |  |
Depth of tumor invasion | ||||
  < 20 mm | Ref |  |  |  |
  ≥ 20 mm | 1.385 (0.856–2.241) | 0.184 |  |  |
Number of Positive Nodes | Â | 0.002 | Â | 0.009 |
 0 | Ref |  | Ref |  |
 1–2 | 1.483 (1.112–1.979) | 0.007 | 1.357 (1.013–1.819) | 0.041 |
 3–4 | 1.725 (1.238–2.402) | 0.001 | 1.549 (1.106–2.171) | 0.011 |
  ≥ 5 | 1.782 (1.203–2.64) | 0.004 | 1.786 (1.202–2.653) | 0.004 |
Lymphovascular invasion (%) | ||||
 No | Ref |  |  |  |
 Yes | 2.581 (0.452–14.724) | 0.286 |  |  |
Primary Tumor Site | Â | 0.245 | Â | Â |
 Tongue | Ref |  |  |  |
 Floor of mouth | 2.625 (0.726–9.486) | 0.141 |  |  |
 Other | 1.306 (0.939–1.817) | 0.113 |  |  |
Extracapsular extension | ||||
 No | Ref |  |  |  |
 Yes | 2.377 (0.583–9.689) | 0.227 |  |  |
Bone invasion | ||||
 No | Ref |  |  |  |
 Yes | 1.244 (0.887–1.743) | 0.206 |  |  |
Safety Margins | ||||
  < 5 mm | Ref |  |  |  |
  ≥ 5 mm | 1.397 (0.766–2.547) | 0.276 |  |  |
SII | Â | Â | Â | Â |
  < 535.5 | Ref |  | Ref |  |
  ≥ 535.5 | 1.724 (1.354–2.194) | < 0.001 | 1.599 (1.25–2.047) | < 0.001 |
NLR | ||||
  < 2.8 | Ref |  | Ref |  |
  ≥ 2.8 | 1.774 (1.09–2.885) | 0.021 | 2.243 (0.751–6.704) | 0.148 |
PLR | ||||
  < 162.5 | Ref |  | Ref |  |
  ≥ 162.5 | 2.472 (1.127–5.424) | 0.024 | 1.204 (0.854–1.699) | 0.289 |