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Table 2 Univariate and multivariate analyses of OS in locally advanced OSCC patients

From: Nomograms to predict the prognosis in locally advanced oral squamous cell carcinoma after curative resection

Characteristics Univariate analysis P Value Multivariate analysis P Value
HR(95%CI) HR(95%CI)
Gender
 Female Ref    
 Male 1.034 (0.908–1.179) 0.612   
Age 1.024 (1.014–1.035) < 0.001 1.023 (1.012–1.033) < 0.001
KFI
  < 2 Ref   Ref  
  ≥ 2 1.389 (1.087–1.776) 0.009 1.458 (1.137–1.871) 0.003
Smoking
 No Ref    
 Yes 1.284 (0.904–1.824) 0.163   
pT   < 0.001   < 0.001
 T1 Ref   Ref  
 T2 2.317 (1.424–3.771) 0.001 2.128 (1.303–3.477) 0.003
 T3 2.869 (1.79–4.598) 0 3.157 (1.945–5.124) 0
 T4 4.317 (2.728–6.831) 0 4.316 (2.674–6.966) 0
pN   .073   .065
 N0 Ref   Ref  
 N1 0.641 (0.445–0.924) 0.017 1.031 (0.701–1.517) 0.876
 N2 0.825 (0.618–1.101) 0.192 1.358 (0.99–1.864) 0.058
 N3 1.078 (0.656–1.773) 0.766 1.685 (1.01–2.811) 0.046
AJCC Stage
 III Ref   Ref  
 IV 1.526 (1.863–1.251) < 0.001 1.358 (0.99–1.864) 0.058
Perineural invasion
 No Ref    
 Yes 1.428 (0.778–2.618) 0.250   
Tumor differentation   0.224   
 Well differentiated Ref    
 Moderately differentiated 1.385 (0.856–2.241) 0.184   
 Poorly differentiated 2.581 (0.452–14.724) 0.286   
Depth of tumor invasion
  < 20 mm Ref    
  ≥ 20 mm 1.385 (0.856–2.241) 0.184   
Number of Positive Nodes   0.002   0.009
 0 Ref   Ref  
 1–2 1.483 (1.112–1.979) 0.007 1.357 (1.013–1.819) 0.041
 3–4 1.725 (1.238–2.402) 0.001 1.549 (1.106–2.171) 0.011
  ≥ 5 1.782 (1.203–2.64) 0.004 1.786 (1.202–2.653) 0.004
Lymphovascular invasion (%)
 No Ref    
 Yes 2.581 (0.452–14.724) 0.286   
Primary Tumor Site   0.245   
 Tongue Ref    
 Floor of mouth 2.625 (0.726–9.486) 0.141   
 Other 1.306 (0.939–1.817) 0.113   
Extracapsular extension
 No Ref    
 Yes 2.377 (0.583–9.689) 0.227   
Bone invasion
 No Ref    
 Yes 1.244 (0.887–1.743) 0.206   
Safety Margins
  < 5 mm Ref    
  ≥ 5 mm 1.397 (0.766–2.547) 0.276   
SII     
  < 535.5 Ref   Ref  
  ≥ 535.5 1.724 (1.354–2.194) < 0.001 1.599 (1.25–2.047) < 0.001
NLR
  < 2.8 Ref   Ref  
  ≥ 2.8 1.774 (1.09–2.885) 0.021 2.243 (0.751–6.704) 0.148
PLR
  < 162.5 Ref   Ref  
  ≥ 162.5 2.472 (1.127–5.424) 0.024 1.204 (0.854–1.699) 0.289
  1. Abbreviations: AJCC American Joint Committee on Cancer, KFI Kaplan-Feinstein index, NLR neutrophil-lymphocyte ratio, PLR platelet–lymphocyte ratio, SII systematic immune-inflammation index