Table 2 The risk groups of HB defined by different collaboration groups
Risk grouping | Grouping criteria |
|---|---|
SIOPEL collaboration groups | |
standard-risk group | PRETEXT I、II or III stage, and AFP > 100 ng/ml |
high-risk group | PRETEXT IV stage, orPRETEXT I、II or III stage with P(portal venous infiltration), V(Hepatic venous or vena cava invasion), E(Intrahepatic metastases), H(tumor rupture), M(distant location), N(Lymph node metastasis), and(or)AFP < 100 ng/ml |
COG collaboration groups | |
Extremely low risk group | Children of simple fetal type and children whose tumor can be surgically removed in PRETEXT I or II stage |
Low risk group | Children of other pathology type and children whose tumor can be surgically removed in PRETEXT I or II stage |
Moderate risk group | Children of other pathology type and who can not be surgically removed in PRETEXT II、III or IV stage |
High risk group | Any child with metastatic lesions or AFP < 100 ng/ml |