New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies

Li, Xi; Li, Yiming; Liu, Guodong; Wu, Wei

doi:10.1186/s12885-021-08092-0

Table 1 Characteristics of the enrolled studies on AXIN2 Polymorphism and cancer

From: New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies

Polymorphism	First author	Year	Ethnicity	Genotyping Method	Source of Control	Cancer Type	Cases			Controls
Polymorphism	First author	Year	Ethnicity	Genotyping Method	Source of Control	Cancer Type	PAA	PAB	PBB	HAA	HAB	HBB	HWE
rs11079571	Wang et al.	2008	Caucasion	GoldenGate	PB	Breast Cancer	32	233	533	16	221	606	Y
rs11079571	Alanazi et al.	2013	Asian	TaqMan	PB	Breast Cancer	182	194	55	11	37	45	Y
rs11079571	Zhang et al.	2015	Asian	PCR	PB	Acute Leukemia	196	180	201	42	170	189	Y
rs1133683	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	172	204	10	42	50	8	Y
rs1133683	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	724	872	6	44	48	8	Y
rs1133683	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	70	306	20	42	50	8	Y
rs1133683	Davoodi et al.	2015	Asian	PCR-RFLP	PB	Ovarian Cancer	386	1210	6	58	34	8	Y
rs1133683	Rosales-Reynoso et al.	2016	Caucasion	PCR-RFLP	PB	Colorectal Cancer	124	252	19	22	57	21	Y
rs1133683	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	190	1406	37	103	169	33	N
rs2240307	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	96	4	0	95	5	0	Y
rs2240307	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	81	3	0	98	2	0	Y
rs2240307	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	93	7	0	95	5	0	Y
rs2240307	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	PA = 182	PB = 194	HA = 212		HB = 238		NA
rs2240307	Han et al.	2016	Asian	PCR	PB	Lung Cancer	63	27	12	79	36	5	Y
rs2240307	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	342	34	0	289	16	0	Y
rs2240308	Kanzaki et al.	2006	Asian	PCR-RFLP	PB	Colorectal Cancer	54	44	15	42	52	15	Y
rs2240308	Kanzaki et al.	2006	Asian	PCR-RFLP	PB	Head and neck Cancer	25	29	9	42	52	15	Y
rs2240308	Kanzaki et al.	2006	Asian	PCR-RFLP	PB	Lung Cancer	81	71	8	42	52	15	Y
rs2240308	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	45	47	8	32	52	16	Y
rs2240308	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	39	45	16	32	52	16	Y
rs2240308	Ferna’ndez-Rozadilla et al.	2010	Caucasion	MassARRAY	HB	Colorectal Cancer	252	423	168	290	442	152	Y
rs2240308	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	30	35	19	34	48	18	Y
rs2240308	Naghibalhossaini et al.	2011	Asian	PCR-RFLP	PB	Colorectal Cancer	34	57	19	55	98	26	Y
rs2240308	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	PA = 196	PB = 180	HA = 226		HB = 226		NA
rs2240308	Mostowska et al.	2013	Caucasion	PCR-RFLP	HB	Ovarian Cancer	67	115	46	71	146	65	Y
rs2240308	Liu et al.	2014	Asian	PCR	PB	Lung Cancer	235	216	47	211	255	67	Y
rs2240308	Ma et al.	2014	Asian	PCR	HB	Prostate Cancer	61	31	11	39	52	9	Y
rs2240308	Aristizabal-Pachon et al.	2015	Caucasion	PCR-RFLP	PB	Breast Cancer	20	58	24	44	55	3	N
rs2240308	Yadav et al.	2015	Asian	PCR-RFLP	PB	Gallbladder Cancer	98	108	44	192	253	119	N
rs2240308	Rosales-Reynoso et al.	2016	Caucasion	PCR-RFLP	PB	Colorectal Cancer	25	109	54	22	59	18	Y
rs2240308	Kim et al.	2016	Asian	GoldenGate	HB	Hepatocellular Carcinoma	124	100	18	246	195	41	Y
rs2240308	Han et al.	2016	Asian	PCR	PB	Lung Cancer	50	34	18	67	43	10	Y
rs2240308	Kim et al.	2016	Asian	Dynamic 96.96 ArrayTM Assay	PB	Lung Cancer	169	142	47	562	436	124	N
rs2240308	Liu et al.	2016	Asian	MassARRAY	HB	Papillary Thyroid Carcinoma	27	24	2	17	29	4	Y
rs2240308	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	99	150	54	81	144	80	Y
rs35285779	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	77	20	3	64	28	8	Y
rs35285779	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	69	15	0	61	32	7	Y
rs35285779	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	70	25	5	64	28	8	Y
rs35285779	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	255	46	2	248	55	2	Y
rs35415678	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	91	9	0	86	14	0	Y
rs35415678	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	83	1	0	99	1	0	Y
rs35415678	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	87	13	0	86	14	0	Y
rs35415678	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	257	46	0	261	44	0	Y
rs3923086	Wang et al.	2008	Caucasion	GoldenGate	PB	Breast Cancer	238	395	164	284	419	139	Y
rs3923086	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	PA = 172	PB = 204	HA = 212		HB = 238		NA
rs3923086	Alanazi et al.	2013	Asian	TaqMan	PB	Breast Cancer	27	41	31	16	42	35	Y
rs3923086	Liu et al.	2016	Asian	MassARRAY	HB	Papillary Thyroid Carcinoma	47	8	0	34	15	1	Y
rs3923086	Parine et al.	2019	Asian	TaqMan	PB	Colorectal Cancer	48	52	21	41	50	19	Y
rs3923087	Wang et al.	2008	Caucasion	GoldenGate	PB	Breast Cancer	47	292	458	39	278	525	Y
rs3923087	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	PA = 70	PB = 306	HA = 130		HB = 320		NA
rs3923087	Mostowska et al.	2013	Caucasion	PCR-RFLP	HB	Ovarian Cancer	10	84	133	14	97	171	Y
rs3923087	Alanazi et al.	2013	Asian	TaqMan	PB	Breast Cancer	45	35	18	24	50	19	Y
rs3923087	Parine et al.	2019	Asian	TaqMan	PB	Colorectal Cancer	35	56	32	37	50	23	Y
rs4072245	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	73	27	0	80	20	0	Y
rs4072245	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	73	11	0	78	22	0	Y
rs4072245	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	82	18	0	80	20	0	Y
rs4791171	Wang et al.	2008	Caucasion	GoldenGate	PB	Breast Cancer	83	332	383	61	349	433	Y
rs4791171	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	PA = 124	PB = 252	HA = 136		HB = 316		NA
rs4791171	Alanazi et al.	2013	Asian	TaqMan	PB	Breast Cancer	34	44	21	22	44	17	Y
rs4791171	Yadav et al.	2015	Asian	PCR-RFLP	PB	Gallbladder Cancer	35	118	97	88	248	228	Y
rs4791171	Parine et al.	2019	Asian	TaqMan	PB	Colorectal Cancer	40	55	27	38	48	24	Y
rs7219582	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	97	3	0	96	4	0	Y
rs7219582	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	81	3	0	95	5	0	Y
rs7219582	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	91	9	0	96	4	0	Y
rs7219582	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	87	205	11	42	263	0	N
rs7224837	Filho et al.	2011	Caucasion	TaqMan	HB	Oral Cancer	342	34		400	50		NA
rs7224837	Mostowska et al.	2013	Caucasion	PCR-RFLP	HB	Ovarian Cancer	161	61	6	203	71	8	Y
rs7224837	Jeanne et al.	2015	Caucasion	iSelect genotyping array	HB	Bladder Cancer	646	151	6	616	169	17	Y
rs9915936	Gunes et al.	2009	Asian	PCR	PB	Lung Cancer	91	9	0	88	12	0	Y
rs9915936	Pinarbasi et al.	2010	Asian	PCR	HB	Prostate Cancer	77	7	0	92	8	0	Y
rs9915936	Gunes et al.	2010	Asian	PCR	HB	Astrocytoma	91	9	0	88	12	0	Y
rs9915936	Bahl et al.	2017	Asian	PCR-RFLP	PB	Lung Cancer	268	29	6	249	51	5	Y

HB Hospital Based, PB Population Based, HWE Hardy Weinberg Equilibrium, Y polymorphisms conformed to HWE in the control group, N polymorphisms didn’t conform to HWE in the control group, NA not available

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