Table 1 Hallmark pathways differentially expressed ssGSEA scores (FDR < 0.10) between concurrent RB1 and TP53 genomically altered and DWT (Wilcoxon rank sum test, two-sided)
Hallmark pathways | Regulation | FDR |
|---|---|---|
E2F_TARGETS | UP | 2.85E-16 |
G2M_CHECKPOINT | UP | 2.00E-14 |
MITOTIC_SPINDLE | UP | 2.52E-13 |
SPERMATOGENESIS | UP | 3.65E-10 |
NOTCH_SIGNALING | DOWN | 1.31E-09 |
MYC_TARGETS_V1 | UP | 1.87E-09 |
ADIPOGENESIS | DOWN | 7.90E-07 |
PANCREAS_BETA_CELLS | UP | 1.27E-06 |
UV_RESPONSE_UP | UP | 1.26E-05 |
DNA_REPAIR | UP | 2.85E-05 |
P53_PATHWAY | DOWN | 4.67E-05 |
UNFOLDED_PROTEIN_RESPONSE | UP | 4.77E-05 |
MTORC1_SIGNALING | UP | 0.00025 |
XENOBIOTIC_METABOLISM | DOWN | 0.00037 |
PEROXISOME | DOWN | 0.00085 |
FATTY_ACID_METABOLISM | DOWN | 0.00222 |
BILE_ACID_METABOLISM | DOWN | 0.023 |
ANDROGEN_RESPONSE | DOWN | 0.028 |
OXIDATIVE_PHOSPHORYLATION | DOWN | 0.028 |
REACTIVE_OXIGEN_SPECIES_PATHWAY | DOWN | 0.032 |
MYC_TARGETS_V2 | UP | 0.034 |
GLYCOLYSIS | UP | 0.051 |
ALLOGRAFT_REJECTION | UP | 0.058 |
INTERFERON_GAMMA_RESPONSE | UP | 0.060 |
TGF_BETA_SIGNALING | DOWN | 0.065 |
MYOGENESIS | DOWN | 0.075 |
INTERFERON_ALPHA_RESPONSE | UP | 0.075 |
INFLAMMATORY_RESPONSE | UP | 0.078 |