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Table 2 Correlation between dynamic contrast-enhanced integrated MR-PET parameters and serum angiogenesis-related biomarkers

From: Assessing tumor angiogenesis using dynamic contrast-enhanced integrated magnetic resonance-positron emission tomography in patients with non-small-cell lung cancer

  VEGF-A (pg/mL) Angiogenin (ng/mL) Angiopoietin-1 (ng/mL)
R2 Slope p-value* R2 Slope p-value* R2 Slope p-value*
MTV (cm3) 0.16 2.26 <  0.001 0.22 1.45 <  0.001 0.22 0.29 <  0.001
SUVmax 0.09 12.67 0.010 0.05 5.34 0.049 0.04 0.96 0.078
ADC (10−6 mm2/sec) 0.03 −0.16 0.184 0.08 −0.16 0.015 0.11 −0.04 0.004
Ktrans (10−3 min−1) 0.14 0.24 0.001 0.11 0.07 0.004 0.26 0.04 <  0.001
kep (10−3 min− 1) 0.31 0.13 <  0.001 0.20 0.06 <  0.001 0.21 0.01 <  0.001
ve (10−3) < 0.01 0.04 0.845 0.01 −0.11 0.384 0.12 0.07 0.002
vp (10−3) 0.05 0.81 0.066 < 0.01 0.06 0.790 0.09 0.13 0.008
iAUC60 (10−3) 0.02 0.13 0.221 < 0.01 0.01 0.926 0.20 0.05 <  0.001
  1. Abbreviations: MR-PET = magnetic resonance-positron emission tomography; VEGF = vascular endothelial growth factor; MTV = metabolic tumor volume; SUVmax = maximum standardized uptake value; kep = reverse reflux rate constant; Ktrans = volume transfer constant; vp = blood plasma volume fraction; ve = extracellular extravascular volume fraction; ADC = apparent diffusion coefficient; iAUC60 = initial area under the time-to-signal intensity curve at 60 s post enhancement
  2. * Significance tested using Pearson’s linear regression analysis
  3. When Bonferroni correction was applied for multiple comparisons (a total of eight MR-PET derived parameters), p-values < 0.006 were considered statistically significant