Table 2 Univariate and multivariate Cox proportional hazards regression analysis for OS
Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) (< 44 vs. ≥44) | 1.253 (0.632–2.482) | 0.518 |  |  |
HPV DNA (pg/ml) (< 1 vs. ≥1) | 0.240 (0.071–0.813) | 0.022 |  |  |
FIGO stage (≤IIA vs. ≥IIB) | 2.373 (0.914–6.158) | 0.076 |  |  |
Pathological type (SCNEC -alone vs. SCNEC -mix) | 1.448 (0.661–3.174) | 0.355 |  |  |
Pre-operative Chemotherapy (No vs. Yes) | 1.148 (0.721–2.787) | 0.312 |  |  |
Post-operative Chemotherapy (No vs. Yes) | 0.514 (0.122–2.161) | 0.364 |  |  |
Post-operative Radiotherapy (No vs. Yes) | 1.558 (0.726–3.342) | 0.255 |  |  |
Tumor size (cm) (< 2 vs. 2–4 vs. ≥4) | 1.528 (0. 890–2.624) | 0.124 |  |  |
Stromal invasion (<  1/2 vs. ≥1/2) | 2.481 (1.026–5.997) | 0.044 | 6.377 (1.397–29.118) | 0.017 |
Endometrial invasion (No vs. Yes) | 1.841 (0.711–4.769) | 0.209 |  |  |
Parametrium invasion (No vs. Yes) | 2.946 (1.276–6.802) | 0.011 | 4.663 (1.496–14.533) | 0.008 |
CIN (No vs. Yes) | 0.667 (0.235–1.898) | 0.448 |  |  |
LNM (No vs. Yes) | 1.697 (0.865–3.326) | 0.124 |  |  |
Nerve invasion (No vs. Yes) | 3.630 (1.814–7.264) | 0.000 | 4.044 (1.514–10.804) | 0.005 |
LVI (No vs. Yes) | 2.150 (0.964–4.797) | 0.061 |  |  |
N-marker (≤2+ vs. > 2+) | 1.777 (0.542–5.829) | 0.343 |  |  |
MMR (pMMR vs. dMMR) | 0.039 (0.001–2.816) | 0.138 |  |  |
Ki67 (< 60 vs. ≥60%) | 1.485 (0.522–4.223) | 0.458 |  |  |
SOX2 (Low vs. High) | 2.658 (1.154–6.125) | 0.022 | 4.437 (1.276–15.428) | 0.019 |
P16INK4A (− vs. +) | 2.646 (0.806–8.690) | 0.109 |  |  |
HR-HPV RISH (− vs. +) | 3.195 (0.961–10.625) | 0.048 | 5.160 (1.098–24.254) | 0.038 |
SOX2/ P16INK4A (AI vs. AII vs. AIII) | 2.457 (1.267–4.766) | 0.008 | 1.593 (0.481–5.274) | 0.446 |
SOX2/ HR-HPV RISH (BI vs. BII vs. BIII) | 3.462 (1.655–7.242) | 0.001 | 3.597 (1.085–11.928) | 0.036 |