Skip to main content

Table 4 Survival analyses associated with immune check point receptor expression in patients with TNBC after NAC

From: TIM3 expression on TILs is associated with poor response to neoadjuvant chemotherapy in patients with locally advanced triple-negative breast cancer

Expressions in TILs N 5-year Disease Free Survival (DFS) (%) p 5-year Disease Specific Survival (DSS) (%) p
PDL-1 ≥ 1% (+) vs < 1% (−) 29/28 62.5% vs 39.5% 0.141 67.2% vs 50.4% 0.132
PDL-1 ≥ 5% (+) vs < 5% (−) 25/32 65.3% vs 38.9% 0.096 66.2% vs 53.3% 0.213
PDL-1 High (≥10%) vs Low (< 10%)a 26/31 66.2% vs 37.5% 0.062 67.6% vs 51.5% 0.145
PDL-1 ≥ 10% (+) vs < 10% (−) 18/39 67.4% vs 42.9% 0.087 69.9% vs 54.0% 0.197
PDL-1 ≥ 20% (+) vs < 20% (−) 15/42 50.0% vs 51.3% 0.996 51.9% vs 62.1% 0.651
PD-1 ≥ 1% (+) vs < 1% (−) 38/23 50.6% vs 61.6% 0.121 51.4% vs 62.7% 0.082
PD-1 ≥ 5% (+) vs < 5% (−) 26/35 54.2% vs 56.1% 0.593 58.1% vs 69.1% 0.270
PD-1 High(≥10%) vs Low(< 10%)a 24/37 56.8% vs 54.8% 0.517 59.6% vs 66.9% 0.263
PD-1 ≥ 10% (+) vs < 10% (−) 10/51 67.5% vs 49.4% 0.193 72.9% vs 57.4% 0.439
PD-1 ≥ 20% (+) vs < 20% (−) 6/55 83.3% vs 52.2% 0.277 83.3% vs 59.5% 0.570
LAG-3 ≥ 1% (+) vs < 1% (−) 16/45 68.8% vs 50.8% 0.370 60.6% vs 59.4% 0.778
LAG-3 ≥ 5% (+) vs < 5% (−) 7/54 57.1% vs 55.3% 0.804 71.4% vs 62.9% 0.339
LAG-3 High(≥10%) vs Low(< 10%)a 6/55 66.7% vs 53.9% 0.815 66.7% vs 61.3% 0.683
TIM3 ≥ 1% (+) vs < 1% (−) 42/19 50.5% vs 65.6% 0.473 53.6% vs 72.3% 0.524
TIM3 ≥ 5% (+) vs < 5% (−) 15/46 52.8% vs 55.4% 0.947 62.7% vs 59.2% 0.959
TIM3 High (≥10%) vs Low (< 10%)a 14/47 57.1% vs 55.2% 0.314 68.8% vs 60.5% 0.535
CTLA-4 ≥ 1% (+) vs < 1% (−) 50/11 57.2% vs 45.5% 0.272 63.2% vs 45.5% 0.209
CTLA-4 ≥ 5% (+) vs < 5% (−) 48/13 55.9% vs 53.8% 0.595 61.8% vs 53.8% 0.481
CTLA-4 High(≥15%) vs Low(< 15%)b 43/18 63.7% vs 36.5% 0.043 70.5% vs 43.2% 0.017
CTLA-4 ≥ 10% (+) vs < 10% (−) 29/32 60.1% vs 51.1% 0.429 67.4% vs 53.6% 0.468
CTLA-4 ≥ 15% (+) vs < 15% (−) 19/42 74.9% vs 46.6% 0.103 74.0% vs 53.8% 0.245
CTLA-4 ≥ 20% (+) vs < 20% (−) 18/43 72.9% vs 48.1% 0.165 72.1% vs 55.0% 0.373
PD1/PDL-1 ≥ 1% (+) vs < 1% (−) 22/38 52.5% vs 51.3% 0.908 58.4% vs 60.4% 0.997
PD1/LAG3 ≥ 1% (+) vs < 1% (−) 14/47 64.3% vs 52.4% 0.619 64.0% vs 61.1% 0.903
PD1/TIM3 ≥ 1% (+) vs < 1% (−) 31/30 48.5% vs 62.2% 0.273 49.4% vs 75.2% 0.204
PD1/CTLA4 ≥ 1% (+) vs < 1% (−) 33/28 58.6% vs 50.2% 0.966 59.9% vs 65.0% 0.984
  1. a > %10&any moderate/strong staining vs other
  2. b > %15&any moderate/strong staining vs other
  3. bold: p < 0.05
\