TIM3 expression on TILs is associated with poor response to neoadjuvant chemotherapy in patients with locally advanced triple-negative breast cancer

Table 1 Spearman correlations (SC) of the immune checkpoint receptor (=ICR) expressions in TILs (n = 61)

		PDL-1	PDL-1_tumor	PD1	LAG3	TIM3	CTLA-4_TILs	CTLA-4_TM
PDL-1_tumor	r	0.772
	*P-value*	< 0.001**
	n	48
PD1	r	0.354	0.352
	*P-value*	0.007**	0.014*
	n	57	48
LAG3	r	0.370	0.476	0.174
	*P-value*	0.005**	0.001**	0.179
	n	57	48	61
TIM3	r	0.256	0.236	0.407	0.274
	*P-value*	0.055	0.106	0.001**	0.033*
	n	57	48	61	61
CTLA-4_TILs	r	0.148	0.068	0.460	0.037	0.301
	*P-value*	0.272	0.648	< 0.001**	0.776	0.018*
	n	57	48	61	61	61
CTLA-4_TM	r	0.131	0.106	0.248	0.251	0.277	0.486
	*P-value*	0.374	0.472	0.076	0.073	0.047*	< 0.001**
	n	48	48	52	52	52	52
MDACC Score	r	−0.061	−0.010	0.153	−0.061	0.062	0.008	0.119
	*P-value*	0.653	0.947	0.244	0.645	0.637	0.953	0.405
	n	56	47	60	60	60	60	51

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