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Table 1 Demographic Information of the Study Subjects Enrolled in a Population-based Case-control Study of Esophageal Squamous Cell Carcinoma, Taixing, China, 2010–2013, stratified by gender

From: A nomogram for screening esophageal squamous cell carcinoma based on environmental risk factors in a high-incidence area of China: a population-based case-control study

Variables

Men

Women

P value for comparing male and female controls b

Controls (N=1373)

N (%)

Cases (N=962)

N (%)

P value a

Controls (N=619)

N (%)

Cases (N=456)

N (%)

P value a

Age at interview (mean±SD, years)

65.6±8.4

65.3±8.5

0.228

67.6±9.4

69.4±7.6

0.024

0.0001

Age group

 40-49

53 (3.86)

30 (3.12)

0.134

29 (4.68)

5 (1.1)

<0.001

<0.001

 50-59

277 (20.17)

215 (22.35)

 

90 (14.54)

35 (7.68)

  

 60-69

586 (42.68)

417 (43.35)

 

209 (33.76)

187 (41.01)

  

 70-79

407 (29.64)

252 (26.2)

 

237 (38.29)

187 (41.01)

  

 80-84

50 (3.64)

48 (4.99)

 

54 (8.72)

42 (9.21)

  

Marital status

 Unmarried

63 (4.59)

55 (5.72)

0.278

5 (0.81)

2 (0.44)

0.575

<0.001

 Married

1160 (84.49)

790 (82.12)

 

428 (69.14)

307 (67.32)

  

 Divorced/Widowed

150 (10.92)

117 (12.16)

 

186 (30.05)

147 (32.24)

  

Occupation

 Farmer

713 (51.93)

517 (53.74)

0.673

547 (88.37)

431 (94.52)

0.002

<0.001

 Worker

356 (25.93)

243 (25.26)

 

45 (7.27)

17 (3.73)

  

 Service/Clerk/Professional/Administrator

304 (22.14)

202 (21)

 

27 (4.36)

8 (1.75)

  

Education

 Illiteracy

171 (12.45)

169 (17.57)

0.002

369 (59.61)

329 (72.15)

<0.001

<0.001

 Primary school

589 (42.9)

419 (43.56)

 

171 (27.63)

109 (23.9)

  

 Junior high school

463 (33.72)

285 (29.63)

 

67 (10.82)

16 (3.51)

  

 High school and above

150 (10.92)

89 (9.25)

 

12 (1.94)

2 (0.44)

  

Family wealth score

 Q1-lowest

288 (20.98)

282 (29.31)

<0.001

120 (19.39)

122 (26.75)

0.024

0.351

 Q2

234 (17.04)

166 (17.26)

 

119 (19.22)

89 (19.52)

  

 Q3

289 (21.05)

216 (22.45)

 

145 (23.42)

106 (23.25)

  

 Q4

297 (21.63)

178 (18.5)

 

132 (21.32)

84 (18.42)

  

 Q5

265 (19.3)

120 (12.47)

 

103 (16.64)

55 (12.06)

  

BMI at 10 years ago

 <18.5 (Underweight)

57 (4.15)

71 (7.38)

<0.001

53 (8.56)

61 (13.38)

0.005

<0.001

 18.5-24) (Normal)

864 (62.93)

652 (67.78)

 

341 (55.09)

251 (55.04)

  

 [24, 28) (Overweight)

367 (26.73)

195 (20.27)

 

178 (28.76)

127 (27.85)

  

 ≥ 28 (Obese)

83 (6.05)

41 (4.26)

 

46 (7.43)

16 (3.51)

  

 Missing

2 (0.15)

3 (0.31)

 

1 (0.16)

1 (0.22)

  

Adult height (cm, male | female)

 ≤ 162 | ≤ 152

500 (36.42)

164 (17.05)

<0.001

244 (39.42)

66 (14.47)

<0.001

<0.001

 (162, 170] | (152, 156]

637 (46.39)

513 (53.33)

 

153 (24.72)

154 (33.77)

  

 (170-174] | (156, 160]

118 (8.59)

131 (13.62)

 

141 (22.78)

152 (33.33)

  

 >174 | >160

116 (8.45)

151 (15.7)

 

80 (12.92)

83 (18.2)

  

 Missing

2 (0.15)

3 (0.31)

 

1 (0.16)

1 (0.22)

  

Frequency of tooth brushing per day

 < 2

903 (65.77)

758 (78.79)

<0.001

387 (62.52)

352 (77.19)

<0.001

0.141

 ≥ 2

452 (32.92)

174 (18.09)

 

225 (36.35)

87 (19.08)

  

 Missing

18 (1.31)

30 (3.12)

 

7 (1.13)

17 (3.73)

  

Sum of missing and filled teeth

 None

370 (26.95)

245 (25.47)

0.177

130 (21.00)

59 (12.94)

0.001

<0.001

 < 6

514 (37.44)

327 (33.99)

 

203 (32.79)

132 (28.95)

  

 ≥ 6

471 (34.3)

358 (37.21)

 

278 (44.91)

240 (52.63)

  

 Missing

18 (1.31)

32 (3.33)

 

8 (1.29)

25 (5.48)

  

Smoking pack-years

 Never

299 (21.78)

153 (15.9)

<0.001

585 (94.51)

413 (90.57)

0.875

<0.001

 ≤ 30

522 (38.02)

327 (33.99)

 

20 (3.23)

15 (3.29)

  

 > 30

531 (38.67)

438 (45.53)

 

4 (0.65)

4 (0.88)

  

 Missing

21 (1.53)

44 (4.57)

 

10 (1.62)

24 (5.26)

  

Alcohol drinking intensity (g/day)

 Never

584 (42.53)

235 (24.43)

<0.001

574 (92.73)

400 (87.72)

0.306

<0.001

 ≤ 80

373 (27.17)

289 (30.04)

 

31 (5.01)

31 (6.8)

  

 > 80

395 (28.77)

397 (41.27)

 

3 (0.48)

1 (0.22)

  

 Missing

21 (1.53)

41 (4.26)

 

11 (1.78)

24 (5.26)

  

Tea drinking temperature

 Never

858 (62.49)

493 (51.25)

<0.001

578 (93.38)

420 (92.11)

0.199

<0.001

 Warm

206 (15)

150 (15.59)

 

19 (3.07)

11 (2.41)

  

 Hot

213 (15.51)

176 (18.3)

 

8 (1.29)

1 (0.22)

  

 Very Hot

76 (5.54)

102 (10.6)

 

4 (0.65)

2 (0.44)

  

 Missing

20 (1.46)

41 (4.26)

 

10 (1.62)

22 (4.82)

  

Family history of esophageal cancer among first-degree relatives

 No

1106 (80.55)

632 (65.7)

<0.001

499 (80.61)

296 (64.91)

<0.001

0.905

 Yes

252 (18.35)

298 (30.98)

 

112 (18.09)

141 (30.92)

  

 Missing

15 (1.09)

32 (3.33)

 

8 (1.29)

19 (4.17)

  

Number of risk factors c

 0 risk factor

8 (0.58)

0 (0)

<0.001

1 (0.16)

0 (0)

<0.001

<0.001

 1 risk factor

48 (3.5)

13 (1.35)

 

7 (1.13)

1 (0.22)

  

 2 risk factors

167 (12.16)

34 (3.53)

 

32 (5.17)

5 (1.1)

  

 3 risk factors

335 (24.4)

116 (12.06)

 

81 (13.09)

16 (3.51)

  

 4 risk factors

402 (29.28)

223 (23.18)

 

184 (29.73)

72 (15.79)

  

 5 risk factors

263 (19.16)

267 (27.75)

 

197 (31.83)

153 (33.55)

  

 6 risk factors

96 (6.99)

198 (20.58)

 

94 (15.19)

133 (29.17)

  

 7 risk factors

22 (1.6)

50 (5.2)

 

10 (1.62)

47 (10.31)

  

 8 risk factors

2 (0.15)

11 (1.14)

 

4 (0.65)

2 (0.44)

  

 Missing

30 (2.18)

50 (5.2)

 

9 (1.45)

27 (5.92)

  
  1. Abbreviations: SD standard deviation, N number, BMI body mass index
  2. a P values were derived using Kruskal–Wallis test for continuous variables and Chi-squared test or Fisher exact test for categorical variables, after excluding the corresponding missing values
  3. b P values were for comparisons between male and female controls
  4. c risk factor were defined as low education level (illiteracy, primary school), family wealth score (Q1, Q2, Q3), BMI (underweight), tooth brushing times (< 2), smoking pack-years (> 0), alcohol consumption intensity (> 0), tea drinking temperature (hot, very hot), and family history of esophageal cancer among first-degree relatives (yes), occupation (farmer), sum of missing and filled teeth (> 0), which were defined based on results from univariate analysis (P < 0.05)