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Table 4 Birth weight and length: associations with luminal and non-luminal breast cancer, by maternal height

From: The association of women’s birth size with risk of molecular breast cancer subtypes: a cohort study

 

Luminal subtypes

Non-luminal subtypes

Maternal height < 163 cm

Maternal height ≥ 163 cm

Maternal height < 163 cm

Maternal height ≥ 163 cm

Cases

Incidence rateb

HR (95% CI)a

Cases

Incidence rateb

HR (95% CI)a

Cases

Incidence rateb

HR (95% CI)a

Cases

Incidence rateb

HR (95% CI)a

Birth weight (g)

  < 3000

32

37.2

1.0 (0.6–1-5)

24

35.2

1.0 (0.6–1.6)

6

7.0

1.0 (0.3–3.3)

3

4.4

0.5 (0.1–2.5)

 3000–3499

82

42.5

1.0 (ref)

71

37.2

1.0 (ref)

10

5.2

1.0 (ref)

10

5.2

1.0 (ref)

 3500–3999

81

56.5

1.3 (1.0–1.8)

74

36.7

1.0 (0.7–1.4)

4

2.8

0.5 (0.2–1.7)

11

5.5

1.1 (0.5–2.7)

  ≥ 4000

21

45.2

1.0 (0.6–1.6)

33

38.3

1.1 (0.7–1.7)

3

6.5

1.1 (0.3–4.2)

5

5.8

1.3 (0.4–3.8)

 Per 500 g

216

46.0

1.1 (0.9–1.3)

202

36.9

1.1 (0.9–1.3)

23

4.9

0.7 (0.7–1.6)

29

5.3

1.3 (0.9–1.9)

Birth length (cm)c,d

  < 49

33

43.9

1.0 (ref)

17

31.2

1.0 (ref)

6

8.0

1.0 (ref)

2

3.7

1.0

 49

29

40.5

0.8 (0.5–1.4)

14

23.8

0.8 (0.4–1.6)

4

5.6

0.9 (0.2–3.5)

2

3.4

1.9 (0.2–11.0)

 50

63

54.8

1.1 (0.7–1.6)

40

34.9

1.1 (0.6–2.1)

7

6.1

0.9 (0.3–3.1)

5

4.4

2.4 (0.3–18.0)

 51

35

40.4

0.9 (0.5–1.4)

41

37.2

1.3 (0.7–2.5)

3

3.5

0.7 (0.1–3.0)

6

5.5

3.5 (0.5–26.3)

  ≥ 52

56

46.4

1.0 (0.6–1.6)

90

43.1

1.6 (0.9–2.9)

3

2.5

0.5 (0.1–2.5)

14

6.7

4.4 (0.6–30.6)

 Per 2 cm

216

46.0

1.0 (0.9–1.2)

202

36.9

1.3 (1.1–1.5)

23

4.9

1.0 (0.7–1.6)

29

5.3

1.5 (1.0–2.2)

  1. aHRs adjusted for gestational age at birth, birth order, birth year in 5 year categories, maternal age at birth, and maternal socioeconomic status
  2. bPer 100,000 person years
  3. cLikelihood-ratio test for the association of birth length with luminal subtypes of breast cancer according to maternal height, p = 0.7
  4. dLikelihood-ratio test for the association of birth length with non-luminal subtypes of breast cancer according to maternal height, p = 0.4