ITGA5 is a prognostic biomarker and correlated with immune infiltration in gastrointestinal tumors

Zhu, Hai; Wang, Gang; Zhu, Haixing; Xu, Aman

doi:10.1186/s12885-021-07996-1

BMC Cancer

Table 1 Correlation analysis between ITGA5 and markers of immune cells in TIMER database

From: ITGA5 is a prognostic biomarker and correlated with immune infiltration in gastrointestinal tumors

Description	Gene markers	COAD				STAD
		None		Purity		None		Purity
		Cor	P	Cor	P	Cor	P	Cor	P
CD8+ T cell	CD8A	0.34	***	0.235	***	0.152	**	0.134	**
CD8+ T cell	CD8B	0.22	***	0.168	***	0.094	0.055	0.094	0.066
T cell (general)	CD3D	0.284	***	0.127	*	0.103	*	0.07	0.175
	CD3E	0.381	***	0.241	***	0.381	***	0.102	0.046
	CD2	0.348	***	0.216	***	0.348	***	0.118	0.021
B cell	CD19	0.226	***	0.072	0.150	0.226	***	0.205	***
B cell	CD79A	0.303	***	0.147	**	0.303	***	0.146	**
Monocyte	CD86	0.651	***	0.583	***	0.651	***	0.313	***
Monocyte	CD115 (CSF1R)	0.65	***	0.584	***	0.65	***	0.423	***
TAM	CCL2	0.607	***	0.607	***	0.659	***	0.427	***
	CD68	0.556	***	0.497	***	0.556	***	0.21	***
	IL10	0.461	***	0.404	***	0.392	***	0.388	***
M1 Macrophage	INOS (NOS2)	0.064	0.172	−0.125	*	0.035	0.475	0.042	0.411
	IRF5	0.296	***	0.323	***	0.193	***	0.197	***
	COX2(PTGS2)	0.41	***	0.359	***	0.402	***	0.398	***
M2 Macrophage	CD163	0.700	***	0.648	***	0.444	***	0.437	***
	VSIG4	0.633	***	0.567	***	0.437	***	0.444	***
	MS4A4A	0.597	***	0.526	***	0.378	***	0.374	***
Neutrophils	CD66b (CEACAM8)	−0.218	***	0.207	***	0.018	0.714	0.045	0.384
	CD11b (ITGAM)	0.684	***	0.624	***	0.427	***	0.418	***
	CCR7	0.405	***	0.274	***	0.319	***	0.292	***
Natural killer cell	KIR2DL1	0.224	***	0.173	***	0.11	*	0.117	****
	KIR2DL3	0.168	***	0.121	0.015	0.039	0.433	0.031	0.553
	KIR2DL4	0.222	***	0.135	**	−0.03	0.549	−0.046	0.375
	KIR3DL1	0.267	***	0.201	***	0.092	0.062	0.076	0.138
	KIR3DL2	0.249	***	0.177	0.177	0.08	0.102	0.074	0.149
	KIR3DL3	0.052	0.265	0.039	0.431	−0.069	0.159	−0.033	0.525
	KIR2DS4	0.194	***	0.162	**	0.051	0.296	0.055	0.284
Dendritic cell	HLA-DPB1	0.501	***	0.389	***	0.136	**	0.101	0.051
	HLA-DQB1	0.297	***	0.183	***	0.068	0.169	0.04	0.441
	HLA-DRA	0.46	***	0.355	***	0.076	0.120	0.044	0.394
	HLA-DPA1	0.486	***	0.385	***	0.09	0.069	0.056	0.281
	BDCA-1(CD1C)	0.304	***	0.199	***	0.246	***	0.213	***
	BDCA-4(NRP1)	0.83	***	0.794	***	0.639	***	0.63	***
	CD11c (ITGAX)	0.738	***	0.675	***	0.408	***	0.392	***
Th1	T-bet (TBX21)	0.43	***	0.336	***	0.183	***	0.172	***
	STAT4	0.343	***	0.231	***	0.222	***	0.222	***
	STAT1	0.451	***	0.411	***	0.076	0.124	0.071	0.169
	IFN-γ (IFNG)	0.242	***	0.183	***	−0.043	0.380	−0.052	0.312
	TNF-α (TNF)	0.383	***	0.334	***	0.236	***	0.204	***
Th2	GATA3	0.442	***	0.36	***	0.22	***	0.204	***
	STAT6	0.132	**	0.121	*	0.199	***	0.214	***
	STAT5A	0.307	***	0.275	***	0.367	***	0.368	***
	IL13	0.3	***	0.247	***	0.167	***	0.19	***
Tfh	BCL6	0.643	***	0.583	***	0.503	***	0.471	***
Tfh	IL21	0.202	***	0.154	**	0.029	0.563	0.012	0.809
Th17	STAT3	0.417	***	0.37	***	0.462	***	0.457	***
Th17	IL17A	0.198	***	0.224	***	−0.103	*	−0.112	*
Treg	FOXP3	0.537	***	0.454	***	− 0132	0.244	−0.107	0.395
	CCR8	0.543	***	0.481	***	0.123	0.280	0.055	0.642
	STAT5B	0.356	***	0.385	***	0.381	***	0.418	***
	TGFβ (TGFB1)	0.69	***	0.606	***	0.6	***	0.591	***
T cell exhaustion	PD-1 (PDCD1)	0.395	***	0.28	***	0.175	***	0.17	***
	CTLA4	0.465	***	0.28	***	0.155	**	0.144	**
	LAG3	0.419	***	0.317	***	0.134	**	0.126	*
	TIM-3 (HAVCR2)	0.645	***	0.584	***	0.33	***	0.33	***
	GZMB	0.099	*	0.077	0.122	0.068	0.169	0.05	0.332

COAD Colon adenocarcinoma, STAD Stomach adenocarcinoma, None: age and tumor purity are not considered (it means that the tumor purity and age are not used to correct the results by using the partial Sperarman’s correlation when performing this association analysis); Purity: tumor purity is considered (it means the tumor purity is used to correct the results when performing correlation analysis); Cor: Correlation coefficient; P:P value; *P < 0.05, **P < 0.01, ***P < 0.001

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