Fig. 6

Impact of ATRX mutation on DNA damage repair. a GSEA analysis showed that the pathways of base excision repair (BER), nucleotide excision repair (NER) and homologous recombination repair (HRR) were significantly enriched in ATRX mutant patients. b Comparison of scores of BER, NER and HRR pathways between patients with or without ATRX mutation. c ATRX mutant female patients showed higher scores of BER, NER and HRR pathways than patients without ATRX mutation. d The expression of core genes in three DDR related pathways between four subgroups. Sub1: female patients with ATRX mutation; Sub2: female patients without ATRX mutation; Sub3: male patients with ATRX mutation; Sub4: male patients without ATRX mutation