Skip to main content

Table 5 Univariate and Multivariate Cox Regression for OS among patients of Breast Cancer with Liver Metastases in the FUSCC dataset

From: Risk and prognostic factors of breast cancer with liver metastases

Variable Overall Survival
Univariate Multivariate
HR (95% CI) P Value HR (95% CI) P Value
Age at diagnosis, y
 21–40 1[Reference]   1[Reference]  
 41–60 1.34 (1.11–1.62) 0.003* 1.38 (1.09–1.74) 0.006*
  > 60 1.39 (1.10–1.75) 0.005* 1.55 (0.86–2.80) 0.145
Histology
 Infiltrating duct carcinoma 1[Reference]   1[Reference]  
 Lobular carcinoma 0.90 (0.56–1.43) 0.648 0.68 (0.41–1.14) 0.146
 Other 0.72 (0.60–0.87) < 0.001* 1.05 (0.85–1.29) 0.661
De novo metastatic diseases
 No 1[Reference]   1[Reference]  
 Yes 0.40 (0.31–0.52) < 0.001* 0.67 (0.29–1.52) 0.337
Surgery of primary site
 No surgery 1[Reference]   1[Reference]  
 Yes 2.33 (1.83–2.98) < 0.001* 1.02 (0.50–2.09) 0.947
Prior Chemotherapy
 No 1[Reference]   1[Reference]  
 Yes 2.56 (1.99–3.28) < 0.001* 1.51 (0.88–2.60) 0.135
Prior Radiotherapy
 No 1[Reference]   1[Reference]  
 Yes 1.33 (1.17–1.51) < 0.001* 1.20 (1.04–1.39) 0.014*
 Unknown 0.77 (0.54–1.08) 0.122 0.67 (0.45–0.99) 0.046*
Recurrent sequence
 First liver metastases 1[Reference]   1[Reference]  
 Subsequent liver metastases 2.16 (1.90–2.46) < 0.001* 1.58 (1.33–1.87) < 0.001*
Extrahepatic metastatic sites to lung, brain, bone and lymph nodes, No
 0 1[Reference]   1[Reference]  
 1 1.54 (1.30–1.83) < 0.001* 1.16 (0.95–1.41) 0.15
 2 2.16 (1.80–2.59) < 0.001* 1.56 (1.23–1.97) < 0.001*
 3 2.57 (2.08–3.18) < 0.001* 2.05 (1.51–2.79) < 0.001*
 All 4 5.49 (3.56–8.47) < 0.001* 4.59 (2.42–8.69) < 0.001*
Subtype
 HR+/HER2− 1[Reference]   1[Reference]  
 HR+/HER2+ 0.82 (0.68–0.98) 0.033* 1.02 (0.83–1.25) 0.851
 HR−/HER2+ 0.84 (0.70–1.01) 0.067 1.13 (0.92–1.40) 0.242
 Triple-negative 1.83 (1.53–2.20) < 0.001* 2.17 (1.78–2.63) < 0.001*
 Unknown 1.11 (0.79–1.57) 0.544 1.63 (1.10–2.43) 0.015*
  1. Notes: + denotes positive; − denotes negative; *denotes a statistically significant P-value; HER2, human epidermal growth factor receptor 2; HR, hormone receptor; CI confidence interval