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Table 3 Univariate and multivariate Cox analysis for BC patients with BM in non-surgery group

From: Surgery for primary tumor benefits survival for breast cancer patients with bone metastases: a large cohort retrospective study

 

Univariate Cox analysis

Multivariate Cox analysis

 

HR

95%CI

P

HR

95%CI

P

Age

  < 51

1

   

1

   

 51–78

1.421

1.219

1.657

0.000

1.425

1.218

1.667

0.000

  > 78

2.247

1.827

2.764

0.000

2.300

1.839

2.875

0.000

Race

 Black

1

   

1

   

 Other

0.732

0.558

0.960

0.024

0.803

0.609

1.059

0.120

 White

0.807

0.687

0.948

0.009

0.795

0.673

0.939

0.007

Sex

 Female

1

       

 Male

1.139

0.659

1.968

0.641

    

Primary site

 Central portion

1

       

 Upper-inner

1.118

0.840

1.487

0.444

    

 Lower-inner

1.237

0.910

1.681

0.174

    

 Upper-outer

1.006

0.804

1.259

0.957

    

 Lower-outer

1.004

0.738

1.367

0.978

    

 Others

1.122

0.894

1.408

0.322

    

Laterality

 Left

1

       

 Right

1.034

0.916

1.168

0.584

    

Histological type

 Ductal

1

   

1

   

 Lobular

1.043

0.881

1.236

0.622

1.239

1.038

1.479

0.018

 Others

1.651

1.292

2.109

0.000

1.450

1.131

1.859

0.003

Grade

 I

1

   

1

   

 II

1.177

0.946

1.464

0.144

1.289

1.032

1.610

0.025

 III

1.662

1.332

2.073

0.000

1.634

1.291

2.067

0.000

 IV

2.917

1.354

6.287

0.006

2.295

1.049

5.021

0.037

T stage

 T1

1

       

 T2

0.880

0.732

1.058

0.174

    

 T3

0.928

0.753

1.145

0.487

    

 T4

1.043

0.861

1.262

0.667

    

N stage

 N0 + N1

1

       

 N2 + N3

1.097

0.936

1.286

0.254

    

Radiotherapy

 No

1

       

 Yes

1.116

0.986

1.264

0.084

    

Chemotherapy

 No

1

   

1

   

 Yes

0.855

0.757

0.966

0.012

0.710

0.613

0.823

0.000

Brain metastasis

       

No

1

   

1

   

Yes

2.113

1.715

2.604

0.000

1.763

1.418

2.192

0.000

Liver metastasis

 No

    

1

   

 Yes

1.569

1.373

1.793

0.000

1.601

1.378

1.859

0.000

Lung metastasis

 No

    

1

   

 Yes

1.403

1.231

1.601

0.000

1.232

1.074

1.413

0.003

Tumor size, cm

  < 2

1

       

 2–5

0.934

0.781

1.116

0.450

    

  > 5

1.016

0.841

1.228

0.867

    

Breast subtype

 HR−/HER2+

1

   

1

   

 HR+/HER2-

0.827

0.635

1.076

0.157

0.872

0.656

1.160

0.348

 HR+/HER2+

0.726

0.538

0.981

0.037

0.713

0.527

0.966

0.029

 HR−/HER2-

3.412

2.500

4.657

0.000

3.320

2.419

4.557

0.000

Insurance status

 Uninsured

1

       

 Insured

1.002

0.758

1.324

0.990

    

Marital status

 Unmarried

1

   

1

   

 Married

0.770

0.681

0.872

0.000

0.850

0.748

0.965

0.012

  1. BC breast cancer, BM bone metastases
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