Fig. 3

Dual drug assays of doxorubicin and lovastatin (N = 7) analyzed by the Loewe additivity model. a. and b. Single agent dose-response data and fitted curves compiled for lovastatin and doxorubicin, respectively. c. Efficacy of the dual-drug combinations overlain with synergy scores. d. Synergy levels calculated by the Loewe model and colored when significant. Only the highest two concentrations of doxorubicin exhibited statistically significant interactions with lovastatin. See the legend of Fig. 2 for details of the plots shown