Table 3 Risk factors associated with multizonal anogenital neoplasia diagnosis at first assessment and/or follow-up
From: Multizonal anogenital neoplasia in women: a cohort analysis
MZN (n=56) | NON-MZN (n= 197) | Testa | p-value | |
|---|---|---|---|---|
Age at first visit (years), median (IQR) | 46 (39-55) | 47 (35-57) | Z= -0.031 | 0.98 |
Age at first HSIL/cancer (years), median (IQR) | 41 (34-49) | 43 (32-55) | Z=1.091 | 0.278 |
Ever smoked, n (%) | 31 (61) | 102 (55) | Chi2(1)=0.472 | 0.50 |
Current smoker, n (%) | 26 (51) | 63 (33) | Chi2(1)=5.42 | 0.02 |
Current smoking pack-years, median (IQR) | 15 (11-21) | 22 (9-35) | Z=0.531 | 0.60 |
HIV-positive, n (%) | 11 (20) | 22 (11) | Chi2(1)=2.82 | 0.10 |
Pharmacologically immunocompromised, n (%) | 15 (27) | 20 (10) | Chi2(1)=10.12 | 0.001 |
Anal sexual intercourse, n (%) | 5 (21) | 32 (31) | Chi2(1)=0.92 | 0.33 |
Time since the 1st anogenital HSIL/cancer diagnosis (years) to first visit, median (IQR) | 3 (1-9) | 4 (1-12) | Z=1.31 | 0.19 |
Previous history of anogenital cancer, n (%) | 14 (25) | 37 (19) | Chi2(1) = 1.12 | 0.31 |
Previous history of HSIL/cancer any site, n (%) | 55 (98) | 136 (69) | Chi2(1)=20.12 | <0.001 |
Previous history of HSIL/cancer by first site | ||||
Cervical, n (%) | 28 (51) | 64 (47) | Chi2(4)=7.72 | 0.10 |
Vulval, n (%) | 19 (35) | 30 (22) | ||
Vaginal, n (%) | 0 (0) | 5 (4) | ||
Anal, n (%) | 7 (13) | 27 (20) | ||
Perianal, n (%) | 1 (2) | 10 (7) | ||