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Table 3 Risk factors associated with multizonal anogenital neoplasia diagnosis at first assessment and/or follow-up

From: Multizonal anogenital neoplasia in women: a cohort analysis

  MZN (n=56) NON-MZN (n= 197) Testa p-value
Age at first visit (years), median (IQR) 46 (39-55) 47 (35-57) Z= -0.031 0.98
Age at first HSIL/cancer (years), median (IQR) 41 (34-49) 43 (32-55) Z=1.091 0.278
Ever smoked, n (%) 31 (61) 102 (55) Chi2(1)=0.472 0.50
Current smoker, n (%) 26 (51) 63 (33) Chi2(1)=5.42 0.02
Current smoking pack-years, median (IQR) 15 (11-21) 22 (9-35) Z=0.531 0.60
HIV-positive, n (%) 11 (20) 22 (11) Chi2(1)=2.82 0.10
Pharmacologically immunocompromised, n (%) 15 (27) 20 (10) Chi2(1)=10.12 0.001
Anal sexual intercourse, n (%) 5 (21) 32 (31) Chi2(1)=0.92 0.33
Time since the 1st anogenital HSIL/cancer diagnosis (years) to first visit, median (IQR) 3 (1-9) 4 (1-12) Z=1.31 0.19
Previous history of anogenital cancer, n (%) 14 (25) 37 (19) Chi2(1) = 1.12 0.31
Previous history of HSIL/cancer any site, n (%) 55 (98) 136 (69) Chi2(1)=20.12 <0.001
Previous history of HSIL/cancer by first site
 Cervical, n (%) 28 (51) 64 (47) Chi2(4)=7.72 0.10
 Vulval, n (%) 19 (35) 30 (22)
 Vaginal, n (%) 0 (0) 5 (4)
 Anal, n (%) 7 (13) 27 (20)
 Perianal, n (%) 1 (2) 10 (7)
  1. HSIL High-grade squamous intraepithelial lesions, IQR Interquartile range, MZN Multizonal anogenital neoplasia cases, NON-MZN Cases with no multizonal anogenital neoplasia ever diagnosed
  2. a We used 1) Mann-Whitney test for continuous outcomes; or 2) Chi-square test for binary outcome.