Fig. 1

Identification of differentially expressed genes (DEGs) in ovarian cancer tissues (n = 57) compared to normal tissues (n = 12) upon analysis of microarray dataset GSE66957. a Volcano plot demonstrates scattering of genes that show significant differences in expression levels between primary ovarian carcinoma and normal ovarian surface epithelial tissue samples. Genes (depicted in orange) show fold change difference of > 2 and a p-value < 0.01. b Heatmap shows expression of 2607 genes that are differentially expressed in ovarian cancer in comparison to normal epithelial tissues. c Clustering analyses group differentially expressed genes into 5 clusters with similar patterns of expression comparing ovarian cancer tissues with normal ovarian epithelium. Gene elements of the 5 DEG clusters are provided in supplementary file 2