Table 6 Panel Regression Models

Cannabis

5.31 (1.68, 8.95)

0.0042

3

< 2.2E-16

Analgesics

−9.3 (−14.93, −3.67)

0.0012

Cigarettes

−4.53 (−7.15, −1.92)

0.0007

Cigarettes: Cannabis

24.47 (11.37, 37.57)

0.0003

4

< 2.2E-16

Cocaine

−11.93 (−22.84, −1.02)

0.0321

Analgesics

−8.25 (−14.2, − 2.3)

0.0066

Cigarettes

−5.83 (−8.92, −2.73)

0.0002

Interactive Full model

White

8.57 (7.18, 9.96)

< 2.2E-16

13,736

< 2.2E-16

Asian

0.92 (0.67, 1.17)

2.0E-12

Hispanic

0.71 (0.47, 0.94)

7.1E-09

Cigarettes

69.38 (39.16, 99.59)

7.9E-06

Cigarettes: Alcohol: Analgesics

1169.92 (598.17, 1741.68)

6.7E-05

Cannabis: Alcohol

719.64 (352.45, 1086.83)

1.3E-04

Cigarettes: Cannabis: Analgesics

2926.99 (1407.72, 4446.25)

0.0002

Analgesics

58.43 (22.7, 94.17)

0.0014

Alcohol: Analgesics

709.96 (139.61, 1280.31)

0.0149

Cannabis: Alcohol: Analgesics

− 5916.9 (− 9125.97, − 2707.83)

0.0003

Cigarettes: Cannabis

− 345.82 (−521.51, − 170.13)

1.2E-04

Alcohol

− 153.51 (−219.89, −87.13)

6.8E-06

Cigarettes: Analgesics

− 716.53 (− 1007.91, −425.15)

1.8E-06

Cigarettes, 2

Cannabis, 2

White

9.28 (7.88, 10.67)

< 2.2E-16

7642

2.0E-01

Analgesics, 2

Asian

0.96 (0.71, 1.22)

2.1E-13

Alcohol, 2

Hispanic

0.67 (0.41, 0.94)

9.4E-07

Cocaine, 2

Cigarettes

18.29 (9.29, 27.29)

7.6E-05

Cigarettes: Alcohol: Analgesics

513.89 (96.6, 931.17)

0.0161

Cigarettes: Analgesics

−92.64 (−154.24, −31.03)

0.0033

Cigarettes: Alcohol

− 95.72 (− 146.79, −44.65)

0.0003

Cigarettes, 4

White

8.71 (6.97, 10.46)

< 2.2E-16

12,537

< 2.2E-16

Cannabis, 4

Hispanic

0.85 (0.54, 1.16)

7.3E-08

Analgesics, 4

Asian

0.72 (0.4, 1.05)

1.7E-05

Alcohol, 4

Cigarettes: Cannabis

233.66 (115.14, 352.18)

1.3E-04

Cocaine, 4

Cigarettes: Alcohol: Analgesics

1975.86 (855.19, 3096.52)

0.0006

Cannabis: Alcohol: Analgesics

1972.91 (573.99, 3371.83)

0.0059

Alcohol

105.37 (17.01, 193.73)

0.0198

AIAN

−8.33 (−14.85, −1.8)

0.0127

Alcohol: Analgesics

− 647.54 (− 1104.4, − 190.68)

0.0057

Cannabis: Alcohol

−376.97 (−619.06, − 134.87)

0.0024

Cigarettes: Alcohol

−286.48 (− 462.48, −110.48)

0.0015

Cigarettes: Cannabis: Analgesics

− 1300.25 (−2003.68, − 596.83)

0.0003

THC

Cigarettes, 5

White

6.7228 (5.29, 8.15)

< 2.2E-16

10

< 2.2E-16

Cannabigerol

Cannabis, 5

Hispanic

0.652 (0.41, 0.89)

7.2E-08

Cannabinol

Analgesics, 5

Asian

0.6755 (0.42, 0.93)

2.6E-07

Cannabichromene

Alcohol, 5

Cigarettes: Cannabis

28.717 (14.28, 43.16)

0.0001

Cocaine, 5

Cigarettes: Cannabis: Alcohol: Analgesics

8122.4789 (3192.57, 13,052.39)

0.0012

Cannabis: Analgesics

463.7354 (130.9, 796.57)

0.0063

Cigarettes: Cannabis: Analgesics

− 1099.2482 (−1927.82, −270.68)

0.0093

Cannabis: Alcohol: Analgesics

− 3523.9404 (− 5495.28, − 1552.6)

0.0005

AIAN

−9.4157 (−14.03, −4.81)

0.0001

Cigarettes

−5.1117 (−7.44, −2.78)

1.7E-05

THC Exposure

In:

White

0.7294 (−11.72, 25.62)

< 2.2E-16

9

< 2.2E-16

Caucas-Am.

Asian

0.1306 (−9.77, 11.17)

9.2E-08

African-Am.

Hispanic

0.1202 (−9.65, 10.91)

1.6E-07

Hispan-Am.

Cigarettes: Cannabis: Alcohol: Analgesics

731.4135 (3112.74, 3129.47)

2.0E-05

Asian-Am.

Cannabis: Analgesics

35.5327 (136.48, 152.42)

4.8E-05

AIAN-Am.

Cocaine

4.9629 (7.98, 18.41)

0.0078

NHPI-Am.

AIAN

2.3266 (−1.45, −16.93)

7.9E-05

Cannabis: Alcohol: Analgesics

378.1363 (− 1752.55, − 1770.82)

3.2E-06

Cigarettes: Analgesics

9.4453 (−37.01, −56.39)

7.7E-07