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Table 5 Univariate analysis and the subsequent multivariate linear regression models of the influential variables on the MN and NPB yields after 21.6 Gy and after 50.4 Gy of RCT

From: Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer

 

After 21.6 Gy RCT

After 50.4 Gy RCT

Univariate

Multivariate

Univariate

Multivariate

p-value

p-value

p-value

p-value

MN yields

 PTVs [cm3]

0.15

0.04

0.002

9.4 × 10−5

 Gender

0.015

0.01

0.017

0.001

 MN/BNL after 3 Gy in vitro

0.006

0.01

1.1 × 10− 4

5.3 × 10−5

NPB yields

 PTVs [cm3]

0.053

0.242

0.001

0.116

 Gender

0.015

0.007

0.054

0.011

 NPB/BNL after 3Gy in vitro

0.116

6 × 10−10

1.0 × 10−5

6.2 × 10− 7

  1. RCT radiochemotherapy, MN micronuclei, NPB nucleoplasmatic bridges, BNL binuclear lymphocytes, PTVs planning target volume size