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Table 5 Univariate analysis and the subsequent multivariate linear regression models of the influential variables on the MN and NPB yields after 21.6 Gy and after 50.4 Gy of RCT

From: Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer

  After 21.6 Gy RCT After 50.4 Gy RCT
Univariate Multivariate Univariate Multivariate
p-value p-value p-value p-value
MN yields
 PTVs [cm3] 0.15 0.04 0.002 9.4 × 10−5
 Gender 0.015 0.01 0.017 0.001
 MN/BNL after 3 Gy in vitro 0.006 0.01 1.1 × 10− 4 5.3 × 10−5
NPB yields
 PTVs [cm3] 0.053 0.242 0.001 0.116
 Gender 0.015 0.007 0.054 0.011
 NPB/BNL after 3Gy in vitro 0.116 6 × 10−10 1.0 × 10−5 6.2 × 10− 7
  1. RCT radiochemotherapy, MN micronuclei, NPB nucleoplasmatic bridges, BNL binuclear lymphocytes, PTVs planning target volume size