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Table 3 Tumor regression grade, acute toxicity, late toxicity (a), and analysis of the correlation between MN and NPB yields and TRG, acute and late toxicity (b). Information on tumor regression grade and late toxicity is missing in 3 and 6 patients, respectively

From: Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer

a

 

Grade 0

Grade 1

Grade 2

Grade 3

Grade 4

TRG

1

14

45

50

19

Acute toxicity

 Skin

50

50

22

10

0

 Bladder

63

55

9

4

1

 Rectum

18

65

31

16

2

 Small bowel

51

54

18

5

4

Late toxicity

 Skin

110

16

0

0

0

 Bladder

105

4

2

14

1

 Rectum

88

12

19

2

5

b

 

MN/BNL

NPB/BNL

 

3Gy in vitro

End RCT (50.4Gy)

3 Gy in vitro

End RCT (50.4Gy)

 

Kendall’s τ [CI]

P

Kendall’s τ [CI]

P

Kendall’s τ [CI]

P

Kendall’s τ [CI]

P

TRG

0.09 [−0.04–0.19]

0.18

−0.02 [−0.13–0.10]

0.78

−0.06 [−0.16–0.07]

0.42

−0.12 [−0.21–0.02]

0.09

Acute toxicity

 Skin

0.10 [−0.01–0.18]

0.13

0.04 [−0.08–0.14]

0.56

0.00 [− 0.12–0.12]

1.00

− 0.09 [− 0.18–0.04]

0.21

 Bladder

− 0.01 [− 0.11–0.10]

0.88

0.06 [− 0.06–0.16]

0.36

0.09 [− 0.04–0.18]

0.21

0.04 [− 0.08–0.13]

0.61

 Rectum

0.13 [0.00–0.21]

0.06

0.02 [− 0.11–0.14]

0.82

− 0.17 [− 0.25 - -0.02]

0.01

− 0.10 [− 0.20–0.03]

0.15

 Small bowel

−0.07 [− 0.17–0.05]

0.28

0.02 [− 0.10–0.13]

0.77

0.04 [− 0.07–0.14]

0.56

0.09 [− 0.04–0.18]

0.21

Late toxicity

0.07 [− 0.06–0.17]

0.30

−0.03 [− 0.15–0.10]

0.67

−0.07 [− 0.16–0.06]

0.33

−0.04 [− 0.14–0.08]

0.61

 Skin

0.00 [− 0.08–0.08]

1.00

−0.12 [− 0.13–0.01]

0.11

0.02 [− 0.07–0.09]

0.75

0.03 [− 0.06–0.09]

0.72

 Bladder

−0.03 [− 0.10–0.07]

0.73

0.01 [− 0.09–0.10]

0.89

−0.10 [− 0.014–0.03]

0.17

−0.03 [− 0–09 - 0.06]

0.68

 Rectum

0.06 [− 0.06–0.14]

0.40

−0.10 [− 0.17–0.03]

0.18

0.04 [− 0.07–0.12]

0.57

0.02 [− 0.09–0.11]

0.83

  1. TRG tumor regression grading, RCT radiochemotherapy; MN: micronuclei, BNL binuclear lymphocytes, NPB nucleoplasmatic bridges