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Table 3 Multivariate analysis for early transplant-related mortality

From: Early transplantation-related mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia

Variables Within 50 days Within 100 days
HR 95% CI p-value HR 95% CI p-value
Older age (≥40) 1.68 (1.20–2.36) 0.003 1.63 (1.34–1.98) < 0.001
Diagnosis
 ALL  Reference     Reference   
 AML 0.75 (0.54–1.05) 0.097 0.82 (0.68–1.00) 0.050
Longer D-to-HCT duration (≥9 months) 2.09 (1.39–3.13) < 0.001 1.58 (1.23–2.03) < 0.001
Previous transplantation 2.51 (1.55–4.08) < 0.001 1.79 (1.28–2.49) 0.001
Previous iron chelation therapy 0.07 (0.02–0.29) < 0.001 0.17 (0.10–0.29) < 0.001
Graft source
 Peripheral blood  Reference     Reference   
 Bone marrow 0.61 (0.37–1.01) 0.054 0.80 (0.61–1.04) 0.097
Cord blood 2.01 (1.11–3.64) 0.022 2.44 (1.73–3.45) < 0.001
Use of ATG 1.07 (0.77–1.50) 0.690 1.17 (0.96–1.42) 0.125
  1. HR Hazard ratio; 95% CI 95% Confidence interval; ALL Acute lymphocytic leukemia; AML Acute myeloid leukemia; D-to-HCT Diagnosis to hematopoietic cell transplantation; ATG Antithymocyte globulin