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Table 3 Multivariate analysis for early transplant-related mortality

From: Early transplantation-related mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia

Variables

Within 50 days

Within 100 days

HR

95% CI

p-value

HR

95% CI

p-value

Older age (≥40)

1.68

(1.20–2.36)

0.003

1.63

(1.34–1.98)

< 0.001

Diagnosis

 ALL

 Reference

  

 Reference

  

 AML

0.75

(0.54–1.05)

0.097

0.82

(0.68–1.00)

0.050

Longer D-to-HCT duration (≥9 months)

2.09

(1.39–3.13)

< 0.001

1.58

(1.23–2.03)

< 0.001

Previous transplantation

2.51

(1.55–4.08)

< 0.001

1.79

(1.28–2.49)

0.001

Previous iron chelation therapy

0.07

(0.02–0.29)

< 0.001

0.17

(0.10–0.29)

< 0.001

Graft source

 Peripheral blood

 Reference

  

 Reference

  

 Bone marrow

0.61

(0.37–1.01)

0.054

0.80

(0.61–1.04)

0.097

Cord blood

2.01

(1.11–3.64)

0.022

2.44

(1.73–3.45)

< 0.001

Use of ATG

1.07

(0.77–1.50)

0.690

1.17

(0.96–1.42)

0.125

  1. HR Hazard ratio; 95% CI 95% Confidence interval; ALL Acute lymphocytic leukemia; AML Acute myeloid leukemia; D-to-HCT Diagnosis to hematopoietic cell transplantation; ATG Antithymocyte globulin