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Table 1 Genes, single nucleotide variants and their biological rationale for inclusion in this study

From: Single nucleotide variants in immune-response genes and the tumor microenvironment composition predict progression of mantle cell lymphoma

Gene SNVs Biological rationale
IL12A rs755004, rs485497, rs568408, rs583911 -Controversial molecule in B-cell lymphoma models (antitumoral effect / exhaustive effect in T-cells) [21, 22];
-SNVs previously associated with lymphoproliferative disorders [16, 23,24,25].
IL2 rs2069762, rs6822844 -Cytokine with potential cytotoxic effect in mantle cell lymphoma [26];
-SNVs previously associated with the regulation of IL2 levels and lymphoma prognosis [15, 27].
IL10 rs3024491, rs1800872, rs1800890 -Cytokine with effects on mantle cell lymphoma proliferation and survival [13, 28];
-SNVs were previously implicated on regulation of IL10 levels and lymphomagenesis [14, 29,30,31].
TGFB1 rs6957, rs1800471, rs1800469 -Pathway with a potential role in mantle cell lymphoma signaling [32];
-SNVs associated with functional changes in the TGFβ pathway [33,34,35].
TGFBR1 rs334348 -Pathway with a potential role in mantle cell lymphoma signaling [32];
-SNV with an effect on cancer risk and postulated functional change [36].
TGFBR2 rs3087465 -Pathway with a potential role in mantle cell lymphoma signaling [32];
-SNV associated with changes in promoter activity [37].
IL17A rs3748067 -Molecule with potential but still uncertain role in B-cell lymphomas’ pathophysiology, including mantle cell lymphoma [38, 39];
-SNV previously associated with prognostic features in cancer, and with a putative functional role [40].
IL17F rs763780 -Molecule with a potential role in B-cell lymphomas, and adverse prognostic role in T-cell lymphoma [38, 39, 41];
-SNV previously associated with alterations in protein function [42].
  1. SNVs Single nucleotide variants