Table 1 Genes, single nucleotide variants and their biological rationale for inclusion in this study

IL12A

rs755004, rs485497, rs568408, rs583911

-Controversial molecule in B-cell lymphoma models (antitumoral effect / exhaustive effect in T-cells) [21, 22];

-SNVs previously associated with lymphoproliferative disorders [16, 23,24,25].

IL2

rs2069762, rs6822844

-Cytokine with potential cytotoxic effect in mantle cell lymphoma [26];

-SNVs previously associated with the regulation of IL2 levels and lymphoma prognosis [15, 27].

IL10

rs3024491, rs1800872, rs1800890

-Cytokine with effects on mantle cell lymphoma proliferation and survival [13, 28];

-SNVs were previously implicated on regulation of IL10 levels and lymphomagenesis [14, 29,30,31].

TGFB1

rs6957, rs1800471, rs1800469

-Pathway with a potential role in mantle cell lymphoma signaling [32];

-SNVs associated with functional changes in the TGFβ pathway [33,34,35].

TGFBR1

rs334348

-Pathway with a potential role in mantle cell lymphoma signaling [32];

-SNV with an effect on cancer risk and postulated functional change [36].

TGFBR2

rs3087465

-Pathway with a potential role in mantle cell lymphoma signaling [32];

-SNV associated with changes in promoter activity [37].

IL17A

rs3748067

-Molecule with potential but still uncertain role in B-cell lymphomas’ pathophysiology, including mantle cell lymphoma [38, 39];

-SNV previously associated with prognostic features in cancer, and with a putative functional role [40].

IL17F

rs763780

-Molecule with a potential role in B-cell lymphomas, and adverse prognostic role in T-cell lymphoma [38, 39, 41];

-SNV previously associated with alterations in protein function [42].