A phase II trial proposal of total neoadjuvant treatment with primary chemotherapy, stereotactic body radiation therapy, and intraoperative radiation therapy in borderline resectable pancreatic adenocarcinoma

Table 1 Flow-chart of study procedures

	Pre-study	PC completion	SBRT completion	Surgery + IORT^a	Follow-up
Assessments					Follow-up
Informed consent	X				3 mo	6 mo	9 mo	12 mo	18 mo	24 mo	30 mo	36 mo
Physical evaluation	X	X	X	X	X	X	X	X	X	X	X	X
AE assessment		X	X	X	X	X	X	X	X	X	X	X
Ca 19–9, CEA	X	X	X	X	X	X	X	X	X	X	X	X
CT-scan (thorax/abdomen)	X	X	X		X	X		X	X	X	X	X
MRI	Optional	Optional	Optional

ISSN: 1471-2407