| |
Univariable
|
Multivariable
|
|---|
|
HR
|
95% CI
|
P
|
HR
|
95% CI
|
P
|
|---|
|
Age
|
1.01
|
(0.99,1.02)
|
0.308
| | | |
|
BMI
|
0.98
|
(0.94,1.03)
|
0.418
| | | |
|
Blood glucose
|
|
Normal
|
ref
| | | | | |
|
Abnormal
|
1.08
|
(0.82,1.44)
|
0.574
|
1.04
|
(0.78,1.4)
|
0.781
|
|
Sex
|
|
Female
|
ref
| | | | | |
|
Male
|
1.07
|
(0.81,1.41)
|
0.621
| | | |
|
Smoking history
|
|
No
|
ref
| | | | | |
|
Yes
|
1.14
|
(0.86,1.51)
|
0.358
| | | |
|
Drinking history
|
|
No
|
ref
| | | | | |
|
Yes
|
1.30
|
(0.94,1.81)
|
0.113
| | | |
|
Diabetes
|
|
No
|
ref
| | | | | |
|
Yes
|
1.05
|
(0.77,1.43)
|
0.771
| | | |
|
Hypertension
|
|
No
|
ref
| | | | | |
|
Yes
|
0.94
|
(0.69,1.27)
|
0.683
| | | |
|
Allergic history
|
|
No
|
ref
| | | | | |
|
Yes
|
1.22
|
(0.83,1.78)
|
0.314
| | | |
|
Abdominal pain
|
|
No
|
ref
| | | | | |
|
Yes
|
1.08
|
(0.8,1.47)
|
0.607
| | | |
|
Back pain
|
|
No
|
ref
| | | | | |
|
Yes
|
0.61
|
(0.4,0.92)
|
0.019
|
0.65
|
(0.42,1.03)
|
0.064
|
|
Anorexia
|
|
No
|
ref
| | | | | |
|
Yes
|
0.86
|
(0.4,1.82)
|
0.689
| | | |
|
Loss of appetite
|
|
No
|
ref
| | | | | |
|
Yes
|
1.09
|
(0.82,1.43)
|
0.559
| | | |
|
Loss of weight
|
|
No
|
ref
| | | | | |
|
Yes
|
0.82
|
(0.62,1.09)
|
0.165
| | | |
|
CA199
|
|
Normal
|
ref
| | | | | |
|
37–1000
|
1.47
|
(1.02,2.12)
|
0.039
|
1.38
|
(0.94,2.01)
|
0.099
|
|
> 1000
|
1.84
|
(1.14,2.97)
|
0.013
|
1.86
|
(1.15,3.02)
|
0.012
|
|
Surgical procedure
|
|
Whipple
|
ref
| | | | | |
|
Distal
|
1.26
|
(0.91,1.75)
|
0.161
| | | |
|
Other
|
0.95
|
(0.44,2.02)
|
0.886
| | | |
|
Location
|
|
Head
|
ref
| | | | | |
|
Tail
|
1.21
|
(0.87,1.69)
|
0.253
| | | |
|
Differentiation degree
|
|
Poor
|
ref
| | | | | |
|
Moderate-high
|
0.79
|
(0.57,1.08)
|
0.144
| | | |
|
AJCC8 staging
|
|
Stage I
|
ref
| | | | | |
|
Stage II
|
1.05
|
(0.77,1.43)
|
0.753
| | | |
|
Stage III-IV
|
1.30
|
(0.9,1.87)
|
0.162
| | | |
|
Obstructive jaundice
|
|
No
|
ref
| | | | | |
|
Yes
|
0.89
|
(0.68,1.17)
|
0.405
| | | |
- HR hazards ratio, CI confidence interval, BMI body mass index, CA cancer antigen, AJCC American Joint Committee on Cancer
