Skip to main content
Fig. 2 | BMC Cancer

Fig. 2

From: Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

Fig. 2

LGR5 expression in colitis associated adenocarcinoma (CAC). CAC with conventional morphology (a) often showed diffuse and strong LGR5 expression (b and c: high power view; score 4), however a few invasive glands adjacent to the LGR5 positive area were LGR5 negative. No morphological differences between these areas was apparent (d). An LGR5 positive invasive component (e) showed nuclear translocation of beta-catenin (f). A high grade mucinous CAC had adjacent dysplasia with focal adenomatous morphology (g). The mucinous component was negative for LGR5 (h); however, nuclear translocation of beta catenin was identified (i). Adjacent dysplasia with adenomatous morphology showed strong LGR5 expression (l) and nuclear expression of beta catenin (m)

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us