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Fig. 9 | BMC Cancer

Fig. 9

From: MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

Fig. 9

Diagram presentation of the molecular mechanism. KDM4B promotes the demethylation of H3K9me3 to reduce the transcriptional suppression of PLK1, while miR-545 directly binds to PLK1 and KDM4B, therefore suppressing PLK1 expression through a direct targeting manner and an indirect regulation through KDM4B, thus alleviating OC development

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BMC Cancer

ISSN: 1471-2407

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