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Fig. 8 | BMC Cancer

Fig. 8

From: MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

Fig. 8

miR-545 mimic suppresses tumor growth and metastasis in nude mice. a-b weight (a) and volume (b) of the xenograft tumors in mice on the 35th d after cell implantation (n = 5 in each group, one-way ANOVA, *p < 0.05); c-e expression of KDM4B (c), PLK1 (d) and VEGFA (e) in cells determined by IHC staining (one-way ANOVA, *p < 0.05); f expression of Ki67 in the collected xenograft tumor tissues examined by IHC staining (one-way ANOVA, *p < 0.05); g area of the lung populated with cancer cells determined by HE staining (n = 5 in each group, one-way ANOVA, *p < 0.05). Representative images are provided. Data were collected from three independent experiments and expressed as mean ± SD

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BMC Cancer

ISSN: 1471-2407

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