Table 4 Univariate and multivariate analyses of OS significance of serum bilirubin and TBA levels

Sex

1.065

0.823–0.232

0.630

Age

0.994

0.984–1.004

0.268

Somking

1.843

1.257–2.703

0.002

1.651

1.117–2.439

0.012

Tumor history

0.703

0.435–1.137

0.703

Obstruction

2.456

1.861–3.241

< 0.001

1.843

1.374–2.473

< 0.001

Tumor size

1.01

0.951–1.072

0.748

 Rectum

Reference

Reference

 Right colon

1.574

1.18–2.101

0.002

1.146

0.811–1.619

0.440

 Left colon

1.56

1.12–2.171

0.008

1.400

0.603–1.111

0.199

 Well

Reference

 Moderate

0.99

0.699–1.402

0.954

 Poor

0.646

0.322–1.296

0.218

 T1

Reference

Reference

 T2

0.875

0.375–2.045

0.758

0.87

0.368–2.058

0.752

 T3

1.803

0.877–3.705

0.109

1.775

0.828–3.805

0.140

 T4

5.968

2.915–12.219

< 0.001

3.486

1.622–7.534

0.001

 N0

Reference

Reference

 N1

2.068

1.512–2.829

< 0.001

1.311

0.861–1.998

0.207

 N2

4.149

3.063–5.620

< 0.001

2.309

1.539–3.466

< 0.001

 I

Reference

Reference

 II

1.914

0.935–3.914

0.076

0.751

0.328–1.719

0.498

 III

4.312

2.184–8.513

< 0.001

1.031

0.446–2.384

0.943

 IV

10.482

5.259–20.893

< 0.001

2.588

1.135–5.902

0.024

 Perineural invasion

0.869

0.632–1.196

0.390

 Vascular invasion

0.952

0.675–1.343

0.781

 Chemotherapy

0.626

0.483–0.810

< 0.001

0.579

0.442–0.76

< 0.001

 TBIL

0.188

0.116–0.303

< 0.001

0.436

0.329–0.578

< 0.001

 DBIL

0.528

0.376–0.742

< 0.001

0.435

0.299–0.637

< 0.001

 TBA

0.26

0.201–0.337

< 0.001

0.206

0.124–0.341

< 0.001