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Table 3 Multivariate Analysis of Prognostic Factors of GBMSS and OS in GBM

From: Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) analysis

Characteristic

HR

GBMSS

p

HR

OS

p

95%CI

95%CI

Age at diagnosis

 Young

1

  

1

  

 Adult

1.1050

0.9530–1.2812

0.1860

1.3528

1.1792–1.5520

< 0.0001

 Old

1.9541

1.6844–2.2669

< 0.0001

2.4902

2.1694–2.8584

< 0.0001

Gender

 Female

1

  

1

  

 Male

1.0135

0.9836–1.0443

0.3807

1.0545

1.0267–1.0830

< 0.0001

Race

 White

1

  

1

  

 Black

0.9457

0.8856–1.010

0.0962

0.9023

0.8515–0.9563

0.0052

 American indian/alaska native

0.8635

0.6879–1.084

0.2059

0.9563

0.7745–1.1808

0.6781

 Asian of pacific islander

0.7924

0.7368–0.8521

< 0.0001

0.7918

0.7417–0.8453

< 0.0001

 Unknown

0.9990

0.6441–1.5495

0.9965

0.4843

0.3319–0.7066

0.0017

Primary site

 Supratentorial

1

  

1

  

 Infratentorial

1.0966

1.0532–1.1419

< 0.0001

1.1105

1.0710–1.1514

< 0.0001

 Brain overlap

1.0451

0.9267–1.1787

0.4721

1.0159

0.9155–1.1274

0.7663

Size

  ≤ 4 cm

1

  

1

  

  > 4 cm

1.1379

1.1033–1.1737

< 0.0001

1.1409

1.1099–1.1727

< 0.0001

Surgery

 Yes

1

  

1

  

 No

1.4743

1.3967–1.5563

0.0014

1.4000

1.3364–1.4666

< 0.0001

 Unknown

1.2474

0.8749–1.7784

0.2220

0.9295

0.6778–1.2746

0.6500

Radiation

 Yes

1

  

1

  

 No

1.4125

1.3425–1.4862

< 0.0001

1.5072

1.4420–1.5754

< 0.0001

Chemotherapy

 Yes

1

  

1

  

 No

1.9379

1.8632–2.0156

< 0.0001

1.9224

1.8571–1.9900

< 0.0001

  1. Abbreviations: HR Hazardous Ratio, CI Credential Interval, OS overall survival, GBMSS GBM specific survival