Table 1 Comparison of clinical and pathological characteristics before hepatectomy for patients with or without statin use
|  | Total (n = 820) | Statin (n = 46) | Non-statin (n = 774) | P-value |
|---|---|---|---|---|
Age (years; median, IQR) | 58.8 (52–66) | 62 (58–63) | 58.6 (52–66) | 0.037 |
Age (>  60 years), n (%) | 432 (52.7%) | 31 (67.4%) | 401 (51.8%) | 0.04 |
Male, n (%) | 639 (77.9%) | 40 (87.0%) | 599 (77.4%) | 0.129 |
Bilirubin (g/dL; median, IQR) | 0.8 (0.6–1.0) | 0.8 (0.5–1.0) | 0.8 (0.6–1.0) | 0.556 |
Albumin (g/dL; median, IQR) | 3.7 (3.2–4.1) | 3.8 (3.5–4.2) | 3.6 (3.2–4.1) | 0.129 |
AFP (>  200 ng/mL), n (%) | 145 (18.2%) | 6 (14.6%) | 139 (18.4%) | 0.547 |
Liver cirrhosis, n (%) | 378 (46.1%) | 12 (26.1%) | 366 (47.3%) | 0.005 |
Hepatitis B, n (%) | 458 (55.9%) | 22 (47.8%) | 436 (56.3%) | 0.259 |
Hepatitis C, n (%) | 284 (34.6%) | 14 (30.4%) | 270 (34.9%) | 0.538 |
Diabetes, n (%) | 214 (26.1%) | 27 (58.7%) | 187 (24.2%) | < 0.001 |
Tumor size (>  2 cm), n (%) | 614 (74.9%) | 42 (91.3%) | 572 (73.9%) | 0.008 |
Tumor number (single:multiple) | 750:70 | 44:2 | 706:68 | 0.296 |
Child-Pugh grade (A:B) | 752:68 | 42:4 | 710:64 | 0.919 |
Microvascular invasion, n (%) | 302 (36.8%) | 22 (47.8%) | 280 (36.2%) | 0.112 |
Histological grade (well:moderate:poor) | 107:684:19 | 6:38:1 | 101:646:18 | 0.965 |
Recurrence, n (%) | 440 (53.7%) | 15 (32.6%) | 425 (54.9%) | 0.003 |
Death, n (%) | 146 (17.8%) | 7 (15.2%) | 139 (18.0%) | 0.637 |