Table 4 Univariable cox proportional hazard model for independent effects of Ann Abor stage, serum LDH, IPI score, ECOG score, location, age, further chemotherapy, further radiation, intrathecal prophylaxis, and tumor size on progression-free survival (PFS) and overall survival (OS)
Variable | PFS | OS | ||
|---|---|---|---|---|
HR | P-value | HR | P-value | |
Advanced stage (III or IV) vs. limited stage (I or II) | 1.6(95%CI, 0.5–5.9) | 0.5 | 5.9(95%CI,1.6–25.0) | 0.009 |
Elevated serum LDH vs. normal serum LDH | 1.0(95%CI,0.4–2.7) | 0.9 | 1.6(95%CI,0.4–6.3) | 0.5 |
IPI score: 3–5 vs. 0–2 | 1.6(95%CI,0.2–2.7) | 0.4 | 3.9(95%CI,1.1–16.7) | 0.04 |
ECOG score over 1 vs. not more than 1 | 1.0(95%CI,0.4–2.7) | 0.9 | 1.7(95%CI,0.4–6.7) | 0.5 |
Location: unilateral vs bilateral | 9.0(95%CI,0.1–36.8) | 0.2 | 8.1(95%CI,0.06–42.0) | 0.5 |
Location: left vs. others | 1.2(95%CI,0.5–3.2) | 0.7 | 0.8(95%CI,0.2–3.2) | 0.7 |
Location: right vs. others | 1.8(95%CI, 0.7–4.7) | 0.3 | 2.2(95%CI, 0.6–8.8) | 0.3 |
Age ≥ 60 vs. age < 60 | 0.9(95%CI,0.3–2.6) | 0.8 | 1.2(95%CI,0.3–5.8) | 0.8 |
Further chemotherapy: NO vs. YES | 3.4(95%CI,1.1–10.9) | 0.03 | 1.8(95%CI,0.4–8.0) | 0.5 |
Further radiation: NO vs. YES | 0.8(95%CI,0.3–2.3) | 0.7 | 1.1(95%CI,0.3–4.7) | 0.9 |
Intrathecal prophylaxis: NO vs. YES | 1.0(95%CI,0.4–2.7) | 0.9 | 0.6(95%CI,0.1–2.6) | 0.5 |
Tumor size (cm):≥5 vs. <5 | 0.7(95%CI, 0.3–2.1) | 0.6 | 1.5(95%CI, 0.4–5.5) | 0.6 |