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Table 2 Univariate and multivariate analyses of overall survival

From: Dissociated responses at initial computed tomography evaluation is a good prognostic factor in non-small cell lung cancer patients treated with anti-programmed cell death-1/ligand 1 inhibitors

 

Univariate analysis

Multivariate analysis

Variables

 

n

HR

95% CI

P

HR

95% CI

P

Age

< 75 vs ≥ 75

51/11

0.70

0.32, 1.55

0.386

   

Gender

Male vs Female

40/22

0.70

0.37, 1.26

0.235

   

PS

0, 1 vs 2–4

46/16

0.25

0.13, 0.48

<  0.001

0.18

0.09, 0.36

< 0.001

Smoking

Never vs Current/Ex

17/45

1.05

0.55, 1.99

0.889

   

Histology

Sq vs non-Sq

10/52

0.93

0.46, 1.89

0.846

   

Driver mutation

Negative vs Positive

47/15

0.59

0.28, 1.23

0.162

   

Treatment line

2nd vs 3rd line

32/30

1.11

0.62, 1.99

0.715

   

PD-L1a

Positive vs Negative

30/8

0.61

0.22, 1.69

0.339

   

Response

DR vs True PD

11/51

0.40

0.18, 0.90

0.027

0.28

0.12, 0.64

0.003

  1. Abbreviations: 95% CI 95% confidence interval, DR dissociated responses, HR hazard ratio for death, PD-L1 programmed cell death-ligand 1, PS performance status, Sq, squamous cell carcinoma, True PD True progressive disease
  2. aPD-L1 positive; PD-L1 ≥ 1%, PD-L1 negative; PD-L1 < 1%
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BMC Cancer

ISSN: 1471-2407

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