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Table 5 Univariate and multivariate Cox regression analysis of the risk factor for poor disease-free survival

From: Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and prognostic nutritional index for predicting clinical outcomes in T1–2 rectal cancer

Parameters

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Age > 60 years vs. ≤60 years

1.480

0.471–4.649

0.502

   

Gender Male vs. Female

2.025

0.645–6.362

0.227

   

Smoking No vs. Yes

0.431

0.097–1.909

0.268

   

Alcoholism No vs. Yes

0.463

0.105–2.025

0.311

   

Hypertension Yes vs. No

2.128

0.772–5.870

0.144

   

Diabetes Mellitus Yes vs. No

1.513

0.427–5.362

0.521

   

Coronary Artery Disease Yes vs. No

2.567

0.817–8.066

0.107

   

CEA level ≥ 5 μg/ml vs. < 5 μg/ml

2.464

0.842–7.211

0.100

   

CA19–9 < 37 U/ml vs. ≥37 U/ml

0.046

< 0.001–1734.515

0.567

   

HGB ≥110 g/L vs. < 110 g/L

0.178

0.057–0.560

0.003

0.205

0.058–0.721

0.014

NLR ≥2.80 vs. < 2.80

6.935

2.466–19.499

< 0.001

6.656

1.616–27.418

0.009

PLR ≥140.05 vs. < 140.05

8.074

1.822–35.790

0.006

1.689

0.313–9.109

0.542

LMR ≥3.88 vs. < 3.88

0.143

0.040–0.508

0.003

0.392

0.096–1.597

0.191

PNI ≥47.1 vs. < 47.1

0.206

0.075–0.568

0.002

1.169

0.308–4.435

0.818

Occult blood No vs. Yes

0.802

0.226–2.843

0.733

   

Distance from anal verge ≤50 mm vs. > 50 mm

1.595

0.508–5.009

0.424

   

Operation procedure Radical resection vs. TEM

1.812

0.511–6.423

0.357

   

Time of operation ≥3 h vs. < 3 h

1.594

0.508–5.006

0.425

   

Blood transfusion perioperation Yes vs. No

3.312

0.435–25.192

0.247

   

Differentiation Poor/Undifferentiate vs. Well/Moderate

1.300

0.734–2.304

0.369

   

Tumor size ≥3 cm vs. < 3 cm

1.869

0.665–5.252

0.235

   

T stage T2 vs. T1

2.918

0.823–10.341

0.097

   

N stage (N1/2 vs. N0)

11.143

3.955–31.400

< 0.001

9.193

2.665–31.712

< 0.001

TNM stage III vs. I

11.143

3.955–31.400

< 0.001

9.193

2.665–31.712

< 0.001

  1. CI confidence interval; HR hazard ratio; CEA carcinoembryonic antigen; CA19–9 carbohydrate antigen 19–9; HGB hemoglobin; NLR neutrophil-to-lymphocyte ratio; PLR platelet-to-lymphocyte ratio; LMR lymphocyte-to-monocyte ratio; PNI prognostic nutritional index; TEM transanal endoscopic microsurgery; TNM tumor-lymph node-metastasis
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BMC Cancer

ISSN: 1471-2407

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